Volume : 09, Issue : 04, April – 2022
Title:
56.FLOATING DRUG DELIVERY SYSTEM: A REVIEW
Authors :
Varsha V R*, Subash Chandran M , Prasobh G R
Abstract :
The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS.
Keywords: Floating drug delivery, Buoyant, Gastric emptying rate, Bioavailability
Cite This Article:
Please cite this article in press Varsha V R et al, Floating Drug Delivery System: A Review., Indo Am. J. P. Sci, 2022; 09(04).,
Number of Downloads : 10
References:
1. Tripathi GK, Singh S: Formulation and In vitro evaluation of pH sensitive oil entrapped polymeric blended buoyant beads of Amoxicillin. Scholar’s research library 2010; 2(2): 131-138.
2. Arora S et.al: Floating drug delivery system: A review. AAPS Pharm SciTech 2005; 6(3): 22-23.
3. Desai S, Bolton SA: Floating controlled release drug delivery system: in vitro- in vivo evaluation. Pharm Res 1993; 10:1321-1325.
4. Mathur P et al: Floating drug delivery system: An innovative acceptable approach in gastro retentive drug delivery. Scholars’ research library 2010; 2(2):257-270.
5. Garg R, Gupta GD: Progress in controlled gastro retentive delivery system. Trop J Pharm Res 2008; 7(3): 1055-1066.
6. Dave BS, Patel M: Gastro retentive drug delivery system of ranitidine HCL formulation and in-vitro evaluation. AAPS Pharm Sci Tech 2004; 235:87-54.
7. Shah SH,Patel JK, Patel NV: Stomach specific floating drug delivery system: A review. IntJ Pharm Tech Res 2009; 1(3): 623-633.
8. Garima, Vishal and Arvind: Gastro retention: A means to address regional variability in intestinal drug absorption. Pharm Tech 2003; 27:50-68.
9. Talukder R,Fissihi R: Gastro retentive delivery system: A mini review. Drug DevInd Pharm Tech 2004; 30: 1019-1028.
10. Gopalakrishnan S, Chenthilnathan: A Floating drug delivery system: A review. J Pharm Sci Tech 2011; 3(2):548-554.
11. Vedhahari et al.: The recent developments on gastric floating drug delivery system: An overview. J PharmTech Res 2010; 2(1): 524-534.
12. Choi BY, Park HJHwang SJ: Preparation of alginate beads for floating drug delivery system effects of CO2 gas forming agents. Int J Pharm 2002; 239: 81-91.
13. Ferdous K, Selim R: Preparation and in-vitro evaluation of theophylline loaded gastro- retentive: Floating tablets of Methocel K4M. Dhaka Univ J PharmSci 2008; 7(1): 65-70.
14. Singh YT, Singh P., Rao: G Development and evaluation of floating microspheres of Verapamil hydrochloride. Brazilian J Pharm Sci 2007; 43 (4):529-534.
15. Vedha H et al.: The recent developments on gastric floating drug delivery system: an overview. Int J Pharm Tech Res 2010, 2(1): 524-534.
16. Arunachalam A et al.: Floating drug delivery system: A review. Int J Res PharmSci 2011; 2(1): 76-83.
17. Mayavanshi AV and Gajjar SS: Floating drug delivery system to increase gastric retention of drugs: A review. Res J Pharm Tech 2008; 1(4): 345-348.
18. Fell JT, Whitehead L and Collet H: Prolonged gastric retention using floating dosage forms. Pharm Tech 2000; 24(3):82-90.
19. Moursy NM, Afifi NH, Ghorab DM, El Saharty Y: Formulation and evaluation of sustained release floating capsules of Nicardipine hydrochloride. Pharm 2003; 58:38-43.
20. Garg S, Shringi S: Gastro retentive drug delivery systems. Pharm Tech 2003: 160-166.
21. Hirtz J, The Gut Absorption of Drugs in Man, A Review of Current Concepts and Methods of Investigation, Br J Clin Pharmacol, 1985; 19: 77S-83S.
22. Ponchel G, Irache JM, Specific and Non-Specific Bioadhesive Particulate System for Oral Drug Delivery to the Gastrointestinal Tract, Adv Drug Del Rev, 1998; 34: 191-219.
23. Davis SS, Stockwell AF, Taylor MJ, Et Al, The Effect of Density on the Gastric Emptying of Single and Multiple Unit Dosage Forms, Pharm Res, 1986; 3: 208-213.
24. Fix JA, Cargill R, Engle K, Controlled Gastric Emptying. III. Gastric Residence Time of a Non-Disintegrating Geometric Shape in Human Volunteers, Pharm Res, 1993; 10: 1087-1089.
25. Groning R, Heun G, Oral Dosage Forms With Controlled Gastrointestinal Transit, Drug Dev Ind Pharm, 1984; 10: 527-539.
26. Groning R, Heun G, Dosage Forms with Controlled Gastrointestinal Passage-Studies on the Absorption of Nitrofurantion, Int J Pharm, 1989; 56: 111-116.
27. Roop K. Khar, Controlled Drug Delivery, Gastroretentive system 4th edn, 202-203.
28. Khan F.N, Dehghan H.G., Int J Health Res, 2009; 2(1): 23
29. Kumar, G. Natural Polymers In The Development Of Floating Drug Delivery Systems: A Review. Int. J. Pharm. Life Sci, 2013; 2(4): 165–178.
30. Darekar, D. An overview on natural gum and its pharmaceutical application. International journal of universal pharmacy and biosciences, December, 2013; 2: 535–547. DOI: 10.1016/j.biomag.2014.02.001.
31. W. ChienYie, Concepts and System Design for Rate Controlled Drug Delivery in Novel Drug Delivery System, 2nd Edn., New york, Marcell Dekker Inc, 1992.
32. Oth M, Franz M, Timmermans J & Moes AJ, The bilayer floating capsule: A stomachdirected drug delivery system for misoprostol, Pharm Res, 1992; 9: 298.
33. Darandale SS & Vavia PR, Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release, Acta Pharmaceutica Sinica B, 2012; 2: 509.
34. Goole J, Hamdani J, Vanderbist F & Amighi K, In vitro and in vivo evaluation in healthy human volunteers of floating riboflavin minitablets, J. Drug Del. Sci. Tech, 2006; 16: 351.
35. Ali J, Arora S, Ahuja A, Babbar AK, Sharma RK, Khar RK & Baboota S, Formulation and development of hydrodynamically balanced system for metformin: In-vitro and invivo evaluation, European Journal of Pharmaceutics and Biopharmaceutics, 2007; 67: 196.