Volume : 09, Issue : 08, August – 2022
Title:
02.FORMULATION AND CHARACTERIZATION OF PHOSPHOLIPID COMPLEX OF APIUM GRAVEOLENS LINN FOR EFFECTIVE DIABETES TREATMENT
Authors :
Sona Thakur*, Dr. Govind Nayak, Mrs. Nisha Thakre, Dr. Parul Mehta*
Abstract :
The present investigation aim to prepare phyto-phospholipid complexes of Apium graveolens has recently received increased attention for treatment of diabetes. The Hydroalcoholic extract of leaves of Apium graveolens had revealed the presence of flavonoids, phenols, protein, carbohydrates, tannins and saponins. Alkaloids, glycosides and diterpenes were found to be absent. Entrapment efficiency is an important parameter for characterizing phytosomes. In order to attain optimal encapsulation efficiency, several factors were varied, including the concentration of the lipid, concentration of drug and concentration of alcohol. The entrapment efficiency of all the prepared formulations is shown in Table. The entrapment efficiency of the phytosomes was found in the range of 50.23±0.36 to 73.32±0.25%. When the regression coefficient values of were compared, it was observed that ‘r2’ values of KorsmeyerPeppas was maximum i.e.0.998 hence indicating drug release from formulations was found to follow KorsmeyerPeppas kinetics. Results of stability studies clearly indicates that optimized batches of phytosomes were stable over the chosen temperature and humidity conditions up to 3 months as were found no significant variation in physical appearance and % drugcontent.
Key words: Apium graveolens, Phospholipid complex, Diabetes treatment
Cite This Article:
Please cite this article in press Sona Thakur et al, Formulation And Characterization Of Phospholipid Complex Of Apium Graveolens Linn For Effective Diabetes Treatment., Indo Am. J. P. Sci, 2022; 09(8).,
Number of Downloads : 10
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