Volume : 09, Issue : 08, August – 2022
Title:
03.SCREENING OF ADIABETIC ACTIVITY OF CRUDE EXTRACT OF CELASTRUS PANICULATUS IN ALLOXAN INDUCED DIABETIC RAT MODEL
Authors :
*Armughan Aymen Mastan, Fatima Sultana, *K. Rama Rao and Anupama Koneru
Abstract :
Diabetes mellitus is a commonest form of endocrine disorder that is characteristic of hyperglycaemia. This is due to a defective metabolic system of fat, proteins, and carbohydrates leading to major health challenges and lifelong microvascular and macrovascular complications. There is the destruction of beta cells of the pancreas that secrete insulin so that insulin is not produced, or defect in release of insulin, or defects in response to insulin by peripheral tissues, that cause hyperglycemiaThe aqueous extract of seeds of Celastrus paniculatus was chosen for the study of antidiabetic action on Alloxan induced diabetic rats.
The preliminary phytochemical screening showed the presence of alkaloids, flavonoids, tannin, carbohydrates, terpenoids, and fixed oils. The administration of CPSE to experimental rats show hypoglycemic action when one dose of CPSE is administered to normal and fasting rats. Additionally, a good glucose clearing capability is seen in the Oral glucose Tolerance Test.
CPSE further shows a gain in body weight of rats in comparison to diabetic rats that show weight loss. Blood glucose levels over the study time period of twenty one days and HbA1c values are also reduced in CPSE administered groups. Total cholesterol, Triglycerides, and LDL levels are augmented and HDL levels are lessened. This is opposed to the values shown by diabetic rats.
Histopathological studies conjointly indicate protecting results of CPSE on pancreatic cells.
Celastrus paniculatus has shown antidiabetic medicinal action, yet its mechanism is not known. Further study may be encouraged that will add to our knowledge and facilitate diabetes treatment.
Cite This Article:
Please cite this article in press Armughan Aymen Mastan et al, Screening Of Adiabetic Activity Of Crude Extract Of Celastrus Paniculatus In Alloxan Induced Diabetic Rat Model., Indo Am. J. P. Sci, 2022; 09(8).,
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