Volume : 09, Issue : 08, August – 2022
Title:
05.DESIGN AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY OF OFLOXACIN TABLETS
Authors :
Tatikayala Ravikumar, Golla Chandramouli, Radapaka Avinash, Lingala Srikanth
Abstract :
The objective of the work is to develop floating tablets of ofloxacin having prolonged gastric residence time after oral administration. Floating tablets of ofloxacin have shown controlled release thereby proper duration of action at a particular site. Floating tablets of ofloxacin were prepared by direct compression technique using polymers like HPMC K4M, HPMC K15M, HPMC K100M, compritol, and xanthum gum as swelling polymers with sodium bicarbonate as a gas generating agent. All formulations were evaluated for their pre and post-compression studies, buoyancy lag time, duration of floating time, in-vitro drug release, and swelling studies. The effect of different concentrations of HPMC on drug release profiles and floating characteristics was studied. The formulation F10 showed drug release 98.45% in 12 hrs; floating lag time was found to be 24 sec and release of drug followed by first order with non-fickian diffusion.
Cite This Article:
Please cite this article in press Tatikayala Ravikumar et al, Design And Evaluation Of Gastroretentive Drug Delivery Of Ofloxacin Tablets., Indo Am. J. P. Sci, 2022; 09(8).,
Number of Downloads : 10
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