Volume : 09, Issue : 08, August – 2022
Title:
06.A CROSS SECTIONAL STUDY ON THE RAISED HOMOCYSTEINE AND ISCHEMIC STROKE
Authors :
Raja Araib Altaf
Abstract :
Objectives: The aim of this study was to determine the frequency of raised homocysteine level in cases presenting with ischemic stroke.
Methodology: The design of this study was a cross sectional study design, this study was carried out at DHQ Hospital Nankana Sahib and the duration of this study was from August 2020 to December 2020. In this study the cases suffering from acute ischemic stroke were included having age more than 30 years of either gender. The cases with protein C and S deficiency and those having any vasculitis and connective tissue disorder were excluded from the study. The diagnosis of ischemic stroke was made by clinical examination of any focal neurological deficit and a hypo dense area on CT brain plain in at least two consecutive slices. Raised homocysteine level was labelled as yes when the level of this is more than 15 µmol/L at fasting time.
Results: In this study 80 cases of acute ischemic stroke were included. The mean age of the cases was 59.11± 11.34 years. There were 25 cases that had history of HTN. Raised homocysteine level was seen in 69 (69%) of the cases. This was seen in 30 (66.7%) of the cases with p= 0.86. There was no significant difference in terms of age groups with p value= 1.0. Raised homocysteine levels were significantly high in cases that had HTN where it was seen in 20 (79.3%) out of 25 cases with p= 0.03.
Conclusion: Raised homocysteine level are very common in cases ischemic stroke and it is significantly high in cases that had HTN.
KEYWORDS: Ischemic stroke, raised homocysteine
Cite This Article:
Please cite this article in press Raja Araib Altaf , A Cross Sectional Study On The Raised Homocysteine And Ischemic Stroke., Indo Am. J. P. Sci, 2022; 09(8).,
Number of Downloads : 10
References:
1. Kim AS, Johnston SC. Global variation in the relative burden of stroke and ischemic heart disease. Circulation. 2011; 124:314–23.
2. Mukherjee D, Patil CG. Epidemiology and the global burden of stroke. World Neurosurg. 2011;76(6):85-90.
3. Han L, Wu Q, Wang C, Hao Y, Zhao J, Zhang L, et al. Homocysteine, ischemic stroke, and coronary heart disease in hypertensive patients: a population-based, prospective cohort study. Stroke. 2015;46(7):1777-86.
4. Fahimfar N, Khalili D, Mohebi R, Azizi F, Hadaegh F. Risk factors for ischemic stroke; results from 9 years of follow-up in a population based cohort of Iran. BMC Neurology. 2012; 12:117-19.
5. Ashjazadeh N, Fathi M, Shariat A. Evaluation of homocysteine level as a risk factor among patients with ischemic stroke and its subtypes. Iran J Med Sci. 2013;38(3):233-39.
6. Sadiq M, Alam MT, Kanpurwala MA, Khan MS. Frequency of hyper-homocysteinaemia in ischemic stroke patients of Karachi. J Pak Med Assoc. 2014;64(9):1063-66.
7. Rahman A, Dasgupta R, Quraishi FA, Saha UK, Ali Z, Hossain S, et al. Association between plasma homocysteine level and ischemic stroke. J Bangladesh Coll Phys Surg. 2013; 31:128-33.
8. Iso H, Moriyama Y, Sato S, Kitamura A, Tanigawa T, Yamagishi K, et al. Serum total homocysteine concentrations and risk of stroke and its subtypes in Japanese.Circulation. 2004; 109:2766–2772.
9. Parnetti L, Caso V, Santucci A, Corea F, Lanari A, Floridi A, et al. Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke. Neurol Sci. 2004; 25:13–17. doi: 10.1007/s10072-004-0219-5.
10. Tay SY, Ampil ER, Chen CP, Auchus AP. The relationship between homocysteine, cognition and stroke subtypes in acute stroke. J Neurol Sci.2006; 250:58–61. doi: 10.1016/j.jns.2006.06.028.
11. Rahman A, Dasgupta R, Quraishi FA, Saha UK, Ali Z, Hossain S, et al. Association between plasma homocysteine level and ischemic stroke. J Bangladesh Coll Phys Surg. 2013; 31:128-33.
12. Shi, Z, Guan Y, Huo YR. Elevated Total Homocysteine Levels in Acute Ischemic Stroke Are Associated With Long-Term Mortality. Stroke.2015; 46: 2419-2425
13. Hung CY, Wang KY, Wu TJ, Hsieh YC, Huang JL, Loh el-W, et al. Resistant hypertension, patient characteristics, and risk of stroke. PLoS One. 2014;9: e104362.
14. Gorgui J, Gorshkov M, Khan N, Daskalopoulou SS. Hypertension as a risk factor for ischemic stroke in women. Can J Cardiol. 2014; 30:774–782.
15. Adunsky A, Weitzman A, Fleissig Y. The relation of plasma total homocysteine levels to prevent cardiovascular disease in older patients with ischaemic stroke. Ageing (Milano) 2000; 12: 48-52.