Volume : 09, Issue : 08, August – 2022
Title:
13.ANTI-TUMOR ACTIVITY OF MERCAPTOPURINE IN COMBINATION WITH PEPPER
Authors :
Amulya DK, Ashoka Shenoy M*, Shabaraya AR
Abstract :
Cancer is one of the most life-threatening diseases and serious health problem in both developing and developed countries. Many synthetic and chemotherapeutic agents used in cancer therapy are having low bioavailability and involve the risk of life-threatening host toxicity. Modern researchers are increasingly showing interest toward the improvement of bioavailability of a large number of drugs by addition of various herbs with bioenhancing properties. In oral drug delivery system, the co-administration of therapeutic agents with natural compounds possessing absorption improving activities, has also garnered great interest. Hence the present study was conducted to evaluate the anti-tumor activity of Mercaptopurine in combination with pepper extract. 20- Methylcholanthrene a Polycyclic aromatic hydrocarbons was used to induce tumor in albino mice. Haematological and endogenous antioxidant parameters were evaluated in the study. Treatment with Mercaptopurine and in combination with pepper extract significantly restored the altered haematological and antioxidant parameters to normal values.
Key words: cancer, bioenhancer, pepper, tumor, Haemoglobin, Lipid peroxidation.
Cite This Article:
Please cite this article in press Ashoka Shenoy M et al, Anti-Tumor Activity Of Mercaptopurine In Combination With Pepper., Indo Am. J. P. Sci, 2022; 09(8).,
Number of Downloads : 10
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