Volume : 09, Issue : 08, August – 2022
Title:
14.DEVELOPMENT AND EVALUATION OF OSMOTIC PUMP TABLETS OF ACECLOFENAC
Authors :
Md Ather Ahmed Abid, Rajesh Babu Vemula, Abdul Sayeed
Abstract :
The aim of the work is to develop & evaluate bilayer-core osmotic pump tablet by wet granulation method, using Aceclofenac as model drug. The prepared bilayer- core osmotic pump tablet will be evaluated for influence of sodium chloride, PEO (WSR Coagulant) and PEG level on drug release profile, etc. The granules of drug layer and push layer were prepared separately by wet granulation method using isopropyl alcohol. The prepared osmotic tablet of Aceclofenac was coated using ethyl cellulose as semi permeable membrane and PEG 400 as pore forming agent, the prepared tablets were evaluated for bulk density, tapped density, compressibility index, angle of repose, weight variation test, hardness, friability, content uniformity and In vitro drug release studied using USP XXIX Paddle method; formulated tablets were also evaluated for effect of pH, effect of agitation, FTIR, the results of IR study showed that there is no interaction between osmo agent, and pure drug.
Results showed that as the concentration of the sodium chloride and PEO (WSR Coagulant) increases it affects the in vitro drug release. Formulation F6 prepared with sodium chloride 65mg, PEO (WSR Coagulant) 37.5mg which exhibited excellent micro meritic properties, percentage yield, and percentage drug release 84.089 % for a period of 12 hrs.Osmotic tablets of Aceclofenac may be an effective alternative to conventional dosage form, which can be effectively used in the treatment of Rheumatoid arthritis.
Keywords: Osmogent, Osmotic pump tablets, Aceclofenac, disintegration time.
Cite This Article:
Please cite this article in press Md Ather Ahmed Abid et al, Development And Evaluation Of Osmotic Pump Tablets Of Aceclofenac., Indo Am. J. P. Sci, 2022; 09(8).
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Number of Downloads : 10
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