Volume : 09, Issue : 08, August – 2022
Title:
31.FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES CONTAINING GRISEOFULVIN
Authors :
Alok Tripathi, Mr. Prashant Mathil, Mr. Satyawan Singh Dangi, Dr. Satkar Prasad
Abstract :
Griseofulvin, an antifungal agent, is a BCS class II drug slowly, erratically, and incompletely absorbed from the gastrointestinal tract in humans. The clinical failure of the conventional oral therapy of griseofulvin is most likely attributed to its poor solubility and appreciable inter- and intra-subject variation in bioavailability from different commercial products. Moreover, the conventional oral therapy is associated with numerous adverse effects and interactions with other drugs. In the proposed research work, we are wanting to get ready transdermal patches of an antifungal drug Griseofulvin with the accompanying goal. Transdermal patches stacked with Griseofulvin will be arranged involving polymers in changing focus by dissolvable vanishing strategy.The pre-arranged transdermal patches will be assessed for different boundaries like weight variety, thickness, collapsing perseverance, drug content, level of dampness content, in-vitro drug release study
Key words: Griseofulvin, transdermal patches, Formulation, Evaluation
Cite This Article:
Please cite this article in press Alok Tripathiet al, Formulation And Evaluation Of Transdermal Patches Containing Griseofulvin., Indo Am. J. P. Sci, 2022; 09(8).
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Number of Downloads : 10
References:
1. Cullins VE. Injectable and implantable contraceptives. CurrOpinObstet Gynecol. 1992; 4:536–543.
2. Langer R. Implantable controlled release systems. Pharmacol Ther. 1983;21:35–51.
3. Zaffaroni A. Systems for controlled drug delivery. Med Res Rev. 1981;1:373–386.
4. Hoffman AS. The origins and evolution of “controlled” drug delivery systems. J Controlled Release. 2008; 132:153–163.
5. Jayaprakash S, Halith SM, Firthouse PM, Yasmin, Nagarajan M. Preparation and evaluation of celecoxib transdermal patches. Pak J Pharm Sci. 2010; 23:279–83.
6. Donbrow M, Samuelov Y. Zero order drug delivery from double-layered porous films: Release rate profiles from ethyl cellulose, hydroxypropyl cellulose and polyethylene glycol mixtures. J Pharm Pharmacol. 1980; 32:463–70.
7. Shoaib MH, Tazeen J, Merchant HA, Yousuf RI. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pak J Pharm Sci. 2006; 19:119–24. 31. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963; 52:1145–9.
8. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1985; 60:110–1.
9. Moore JW, Flanner HH. Mathematical comparison of curves with an emphasis on in vitro dissolution profiles. Pharm Tech. 1996; 20:64–74.