Volume : 09, Issue : 08, August – 2022
Title:
32.FORMULATION AND CHARACTERIZATION OF MECLIZINE FLOATING GASTRORETENTIVE TABLETS USING SOME SYNTHETIC AND NATURAL POLYMERS
Authors :
Shraddha Soniya*, Rishikesh Sharma
Abstract :
Gastroretentive drug delivery system (GRDDS) is one of the novel approach in this area. Oral controlled release dosage forms are the most commonly formulated but still offer highest attention in the area of novel drug delivery systems. Meclizine hydrochloride (MCZ) is a first-generation antihistamine of the piperazine class drug, used in the treatment of motion sickness (H1 receptor antagonist). Meclizine is a white to light yellowish-white crystalline powder and practically insoluble in water. Meclizine has a plasma elimination half-life of about 5-6 hours in humans and dose 12.5-50 mg PO given 1 hour before travel. The aim of present work to formulate and characterize sustain release gastro-retentive floating tablets of Meclizine hydrochloride using some synthetics and natural polymers like HPMCK4, HPMC K15, PVP K30, guar gum or Gum tragacanth. The % drug content of all the formulated tablets were found within the limit. % drug content value of Meclizine was within 98.12±0.45% to 99.45±0.32%.The results within the range indicate uniform of mixing. The in vitro drug release was carried out for formulation (F1, F2, F3, F4, F5, F6, F7 and F9 Formulation and release kinetics was calculated for optimized formulation F7. When the regression coefficient values of were compared, it was observed that ‘r2’ values of first order was maximum i.e. 0.980 hence indicating drug release from formulations was found to follow First order release kinetics.
Keywords: Gastroretentive drug delivery system, Meclizine hydrochloride, Synthetic and Natural Polymers
Cite This Article:
Please cite this article in press Shraddha Soniya et al, Formulation And Characterization Of Meclizine Floating Gastroretentive Tablets Using Some Synthetic And Natural Polymers., Indo Am. J. P. Sci, 2022; 09(8).
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Number of Downloads : 10
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