Volume : 09, Issue : 08, August – 2022
Title:
33.FORMULATION DEVELOPMENT AND EVALUATION OF ADAPALENE CONTAINING ETHOSOMAL GEL FOR TREATMENT OF ACNE
Authors :
Mr. Shubham Mishra, Dr. Deepak Kumar Basedia, Dr.B. K. Dubey
Abstract :
In this study an attempt has been made to formulate a supplement dermal therapy of Adapalene. The ethosomal encapsulation of Adapalene was found to increase the skin residence time leading to a faster healing of external lesions and to a reduction of side effects and duration of therapy. Adapalene ethosomes prepared by hot technique with required modifications after optimizing formulation variables. Ethosomes were prepared and optimized on the basis of average vesicle size, and % drug entrapment. The optimized formulation was further encorpoated with gel base (carbapol gel) and characterized for their viscosity, extrudability, spreadability and drug release study. It was found that in all formulation formulation F2 select as a optimized formulation because of its good Spreadability (13.25±1.1), Viscosity (3215) and pH (66.80). The maximum % assay was also found in formulation F2 (95.21±0.15). In vitro drug release from ethosomal gel was carried out using Frenze diffusion cell method and found 96.75% in 12 hr. In first 30 min it was 25.65% drug release which slightly high. It was due to the release of free drug present in bag after leaching from liposomes. Drug release from ethosomes formulation was found in very sustained and controlled manner.
Keywords: Adapalene, Ethosomal, Acne, Formulation, Evaluation
Cite This Article:
Please cite this article in press Shubham Mishra et al, Formulation Development And Evaluation Of Adapalene Containing Ethosomal Gel For Treatment Of Acne., Indo Am. J. P. Sci, 2022; 09(8).
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Number of Downloads : 10
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