Volume : 09, Issue : 08, August – 2022
Title:
39.FORMULATION AND EVALUATION OF ANTIOXIDANT ACTIVITY OF HERBAL PAPAYA SOAP
Authors :
Amol Supekar, Sandip Khandagale, Sakshi Shinde, Snehal Thorat, Shital Rokade
Abstract :
Plants have long been thought to be a rich source of bioactive chemicals with medicinal properties, according to traditional medicine. Carica papaya Linn, often known as pawpaw, is a monoecious, dioecious, or hermaphrodite tree that belongs to the Caricacea family. It is known as a nutraceutical fruit and can be employed as a valuable and promising natural medicinal plant due to its antioxidant, antibacterial, antihelminthic, antifungal, antihypertensive, antifertility, and free radical scavenging characteristics. As a result, C. papaya is regarded as the king of medicine due to its extensive pharmacological potential and medicinal benefits of various papaya sections. The current study is concentrating on the nutritional benefits of papaya as a natural therapeutic plant.
A produced active component consisting of crude papain enzyme is a solid soap formulation with antioxidant origin from fresh papaya, and it may be employed as soap in this research work to improve human skin health. The benefits of adding crude papain enzymes that are safe for the skin were investigated in this study, with the goal of creating a solid soap formula that fulfils SNI 1996 standards. Formula IV, which complies with SNI 1996, is a soap formula, and other formulae with an IC50 value of 13,657 ppm have the maximum antioxidant activity. When compared to soap, the % dirt removal value for the negative control (with enzyme) is higher.
Papaya (Carica papaya linn) is well-known around the world for its remarkable nutritional and therapeutic benefits. The entire Papaya plant, including its leaves, seeds, ripe and unripe fruits, and their juice, has been utilised as a traditional medicine since time immemorial. The fruit is oval in shape with a yellowish-green exterior and yellow flesh.
Keywords: papain, antioxidant, solid soap, carica papaya linn.
Cite This Article:
Please cite this article in press Amol V. Supekar et al, Formulation And Evaluation Of Antioxidant Activity Of Herbal Papaya Soap., Indo Am. J. P. Sci, 2022; 09(8).
,
Number of Downloads : 10
References:
1. Klein BEK, Klein R, Lee KE. Cardiovascular disease, selected cardiovascular disease risk factors and age related cataracts: The beaver dam eye study. Am J Ophthalmol 1997;123:338-46.
2. Unakar NJ, Tsui JY. Inhibition of galactose induced alteration in ocular lens with sorbinil. Exp Eye Res1983;36:685-94.
3. Cheng HM, Fagarhoilm P, Chylack LT. Response of lens to oxidative-osmotic stress. Exp Eye Res 1983;37:11-21.
4. Gupta SK, Joshi S, Velpandian T, Awor L, Prakash J. An update on pharmacological prospectives for prevention and development of cataract. Indian J Pharmacol 1997;29:3- 10.
5. Gillis CN, Chen X, Merker MM. Lisinopril and ramiprilat protection of the vascular endothelium against free radical-induced functional injury. J Pharmacol Exp Ther 1992;262:212-6.
6. Hayek T, Attias J, Breslow JL, Keidar S. Antiatherosclerotic and antioxidative effects of captopril in apolipoprotein-E-deficient mice. J Cardiovasc Pharmacol1998;31:540-4.
7. Peroxide productiRuiz-Munoz LM, Vidal-Vanaclocha F, Lampreabe I. Enalaprilat inhibits hydrogen on by murine mesangial cells exposed to high glucose concentrations. Nephrol Dial Transplant1997;12;456-64.
8. Elena MV, de Cavanagh EM, Inserra F , Ferder L, Fraga CG. Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues. AJP-Regulatory, Integrative and Comparative Physiology 2000;278:R572-77.
9. Chandorkar AG, Albal MV, Bulakh PM. Muley MP. Lens Organ Culture. Indian J Opthalmol1981;29:151-2.
10. Unakar NJ, Tsui JY. Measurement of Na+-K+-ATPase activity. Invest Opth Vise Sci 1980;19:378-85.
11. Lowry O, Rosebrough A, Farr A, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem1951;193:265.
12. Wilbur KM. Estimation of lipid peroxide. Arch Biochem Biophysics1949;24:30515.
13. Akula Srujana, N Navya Priya and Anis Mirza ,Study on Papaya Antioxidants and Solid Soap Formulation Based on Crude Papain, (2020) , vol 9(11),Page no. 368-373.
14. Maria A. A. R. Fonseca, Aakanksha N. Karpe, P.S. Keerthi, Ryan Mathias Mendes, Fruit Peel soap and its Antibacterial Properties in Skin Care,(2019), Vol 11(3) , Page no 17-20.
15. Sandhya L Borse ,Meghawati R. Badwar , Dr. Laxmikant B. Borse , Dr. Anil G. Jadhav , Formulation and Evaluation of Two Layered Soap Containing Orange Peel Extract (2019) vol 11 (6), Page no 2190-2192.
16. G. Sucharita , V. Ganesh, B. Siva Krishna, Formulation and Evaluation of Poly herbal Anti-Bacterial Soap,(2020), Vol 10(8) Page no 27165-27173.
17. Navneet Kumar Varma, Asha Roshan , Anubha Gupta, (2014), Vol 2(4), Page no 541-542.
18. Setiadi, Putri and Familia Anindia 2nd International Tropical Renewable Energy Conference, Manufacture of Solid Soap Based on Crude Papain Enzyme and Antioxidant from Papaya, (2018), Page no 1-7.
19. Ashlesha Ghanwat, Sachin Wayzod and Vanjire Divya Formulation and Evaluation of Herbal Soap (2020) , Vol 2(2) , Page no 21-26.
20. Munde Govind Anant, Formulation and Evaluation of Herbal Soap by using Natural Ingredients by Simple Matched, (2021), Vol 3(11) , Page no 172-176.
21. Rakesh K. Sindhu, Mansi Chitkara, Gagandeep kaur , Arashmeet Kaur , Sandeep Arora, Formulation, Developement and Anti-Microbial Evaluation of Poly Herbal Soap, (2019), Vol 19(2), Page no 1343-1346.
22. Parle Milind and Gurditta, Basketful Benefits of Papaya (2011),Page no 6-12.
23. C. K. Kokate, A.P. Purohit , S.B. Gokhale, Pharmacognosy, Nirali Prakashan, 50th edition,( 2014), Page no 14.91-14.94.
24. Varro E. Tyler, Lynn R. Brady,James E. Robbers, Pharmacognosy, 9th edition, Page no 293-294.
25. C. K. Kokate, A.P. Purohit, S. B. Gokhale ,Pharmacognosy ,Nirali Prakashan,4th edition,(2013), Page no 12.9- 12.10.
26. C.K. Kokate ,A. P. Purohit , S.B. Gokhale,Pharmacognosy, Nirali prakashan, 50th edition (2014) , Page no 8.40-8.41.
27. Dr.Rajesh A Sahu, Mrs. Rashmi R. Mishra, Madhav P. Sonekar , Pharmacognosy and Phytochemistry-ll, edition (2019).
28. Nandini,Khizra Khanum,Gopenath, Raviraja , Nagalambika Prasad and Kanthesh M Basalingappa, A Review on Significance of Carica Papaya linn: A Promising Medicinal Plant ,Vol 11 (2), Page no 37606.