Volume : 09, Issue : 12, December – 2022
Title:
102.FABRICATION AND IN VITRO EVALUATION OF FINGOLIMOD FAST DISSOLVING TABLETS BY USING SOLID DISPERSION TECHNIQUE
Authors :
Fatima Khatoon, R. Venu Priya*, Niranjan Panda, A Venkateshwar Reddy
Abstract :
The goal of the current study was to increase the solubility and rate of dissolution of Fingolimod using solid dispersion technology. This was accomplished by using amorphous alloys made from high molecular mass polymers, such as PEG 4000 and PEG 6000, which significantly increased solubility compared to the crystalline form. The procedure of physical mixing and solvent evaporation was used to create solid dispersions. Different drug and carrier ratios, including 1:1, 1:2, 1:3 and 1:4 were utilized in the preparation. Pure drug and solid dispersion phase solubility investigations were conducted. It was discovered that Fingolimod’s solubility has risen. The drug content was consistent across all batches of solid dispersions and was found to be in the form of fine, free-flowing powders in all cases. Physical and thermal compatibility between the medication and polymer was validated by compatibility investigations like FTIR and DSC analysis. The results generated with pharmacopeial specifications were confirmed by precompression and after compression parameters. All of the solid dispersions of Fingolimod dissolved quickly, with a dissolution rate that was many times higher than that of the comparable pure drug and that followed zero order kinetics. Dissolution rates in solid dispersion were higher than in physical mixes. PEG 6000, a medication, had the quickest dissolution (1:3). In the current work, solid dispersion techniques were effectively used to generate the fast-dissolving tablet formulation of fingolimod, and the solubility and dissolution profiles of drugs with low water solubility, such fingolimod, have improved. In the future, preclinical and clinical analysis will be used to evaluate the therapeutic effectiveness of formulations.
Key words: Solid dispersion, Fingolimod, PEG 4000, PEG 6000
Cite This Article:
Please cite this article in press R. Venu Priya et al, Fabrication And In Vitro Evaluation Of Fingolimod Fast Dissolving Tablets By Using Solid Dispersion Technique..,Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
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