Volume : 09, Issue : 12, December – 2022
Title:
105.FORMULATION AND IN- VITRO EVALUATION OF MOLNUPIRAVIR GASTRORETENTIVE MICROSPHERES
Authors :
Y. Ramulu
Abstract :
The present study involves formulation and evaluation of sustained release floating microspheres of Molnupiravir sulphate. Endeavour‟s with respect to floating mechanism are inculcated in the formulation to achieve longer stay of microsphere in stomach which happen to better site of absorption for the selected drug. Preformulation studies involving organoleptic bulk density, tapped density, angle of repose, compressibility of index, hausner ratio, melting point range, pH, solubility were carried out as per IP specification. Drug excipient compatibilities were carried out and evaluation and FT-IR, SEM. This showed no significant change in any way to the Mixture. Different polymers like sodium alginate, sodium carboxy methyl cellulose, HPMC K4M, HPMC K100M were utilized in the trials. All the physical evaluations are carried in preformulation studies were carried out on all the three different polymers utililized. All the formulations exhibited values within the acceptable range. Microspheres were evaluated for buoyancy studies, drug entrapment efficient. Release studies were carried out in 0.1N HCL for 12 hours. Evaluated samples for all the four polymer system. Results indicated that formulation F7, gave 90.12 % release up to 12 hrs which is formulated with HPMC K100M and HPMCK4M combination. Assay was carried out for formulation F7 and was found to be 88.69 %. The mechanism of drug release from microspheres follows Non-Ficknian release.Remaining formulations gave fluctuating release profiles. The formulation F7 was considered to be better among the trails accomplished.
Keywords: Formulation Design, Development, In- Vitro Evaluation, Molnupiravir, Gastroretentive, Microspheres
Cite This Article:
Please cite this article in press Y. Ramulu, Formulation And In- Vitro Evaluation Of Molnupiravir Gastroretentive Microspheres.,Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
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