Volume : 09, Issue : 12, December – 2022
Title:
106.PHARMACOLOGICAL EVALUATION OF PHYLLANTHUS NIRURI FOR HEPATOPROTECTIVE ACTIVITY IN CARBON TETRACHLORIDE-INDUCED WISTAR RATS
Authors :
Gaddam Sushma
Abstract :
In the current research, CCl4-induced Wistar rats were given an ethanolic extract of the Phyllanthus Niruri (EEPN). This extract was tested for its potential to safeguard the liver. Carbon tetrachloride (CCl4) is an initiating agent through the intraperitoneal route. Silymarin is a standard drug at a dose of 50 mg/kg body weight. The treatment consisted of giving the patient daily dosages of EEPN ranging from 250 mg/kg to 500 mg/kg for twenty days. They utilized diagnostic tools to evaluate various parameters, including some biochemical parameters such as SGOT, SGPT, ALP, TB, TC, and TG. After the experiment, the animals were slaughtered, their livers have removed, rinsed with salt water, and their weight and recorded the volume. After being preserved in formalin at a concentration of 10%, a sample of liver tissue was subsequently used for histopathological examination. A one-way analysis of variance (ANOVA) was used to conduct the statistical analysis of the data, and a Tukey post hoc multiple comparison test followed this.
Keywords: Phyllanthus Niruri, Hepatoprotective activity, CCl4, and silymarin
Cite This Article:
Please cite this article in press Gaddam Sushma, Pharmacological Evaluation Of Phyllanthus Niruri For Hepatoprotective Activity In Carbon Tetrachloride-Induced Wistar Rats.,Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
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