Volume : 09, Issue : 12, December – 2022
Title:
28.DEVELOPMENT AND CHARACTERIZATION OF ESOMEPRAZOLE LOADED NANOSPONGES FOR TREATMENT OF GASTRIC ULCER
Authors :
Awinish Kumar Shrivastaw, Dr. Vivek Gupta*
Abstract :
Ulcers are sores or eroded areas that form in the lining of the digestive (gastrointestinal) tract. They usually occur in the stomach (gastric ulcer) or in the duodenum (duodenal ulcer). Proton pump inhibitors (PPIs) are the most potent inhibitors of gastric acid secretion available, and they are effective for treating all acid-related disorders Esomeprazole is indicated for the treatment of gastroesophageal reflux disease in adults and children, risk reduction of NSAIDs-associated gastric ulcer, Helicobacter pylori eradication and control of pathological hypersecretory conditions associated with Zollinger–Ellison syndrome. Nowadays, targeting drug delivery is the major problem which is being faced by the researchers. Target oriented drug administration with improvements in therapeutic efficacy, reduction in side effects and optimized dosing regimen, shall be the leading trends in the area of therapeutics. Nanosponges are a new class of materials and made of microscopic particles with few nanometers wide cavities, in which a large variety of substances can be encapsulated. These particles are capable of carrying both lipophilic and hydrophilic substances and of improving the solubility of poorly water soluble molecules. The aim of this study is to formulate & evaluate nanosponge loaded with Esomeprazole. The nanosponge was prepared by standard methods & evaluated for various parameters.
The result showed that the bulk density and the tapped density for all the formulations varied from 0.345 to 0.385gm/cm3 and 0.458 to 0.492gm/cm3 respectively. The result of Hausner’s ratio of all formulations ranges from 1.278 to 1.328. Compressibility index of all the formulations ranges from 21.75% to 24.67%. The kinetics study revealed that formulations was found to follow Zero order of drug release kinetics. The actual drug content of prepared nanosponge’s formulation F1, F2, F3, F4, F5 and F6 was found to be 94.45±0.32, 92.23±0.25, 97.74±0.15, 99.45±0.26, 98.85±0.36 and 92.23±0.14 respectively. The maximum drug content was found in formulation F3 (99.45±0.26). The Encapsulation efficiency of formulation F1, F2, F3, F4, F5, and F6 was found 74.56±0.22, 73.36±0.25, 85.45±0.36, 78.85±0.14, 82.23±0.25 and 81.14±0.35. The maximum encapsulation efficiency was also found maximum in formulation F3 (85.45±0.36). It can be concluded that F3 nanosponge of Esomeprazole can be used for treating gastric ulcer as it exhibits all ideal characteristics.
Keywords: Nanosponge, Gastric ulcer, Esomeprazole, Targeted drug delivery
Cite This Article:
Please cite this article in press Vivek Gupta et al, Development And Characterization Of Esomeprazole Loaded Nanosponges For Treatment Of Gastric Ulcer.., Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
References:
2. Calam J, Baron JH. Pathophysiology of duodenal and gastric ulcer and gastric cancer. Bmj. 2001 Oct 27;323(7319):980-2.
3. Vachhani R, Olds G, Velanovich V. Esomeprazole: a proton pump inhibitor. Expert Review of Gastroenterology & Hepatology. 2009 Feb 1;3(1):15-27.
4. Selvamuthukumar S, Anandam S, Krishnamoorthy K, Rajappan M. Nanosponges: A novel class of drug delivery system-review. Journal of Pharmacy & Pharmaceutical Sciences. 2012 Jan 17;15(1):103-11.
5. Ahmed RZ, Patil G, Zaheer Z. Nanosponges–a completely new nano-horizon: pharmaceutical applications and recent advances. Drug development and industrial pharmacy. 2013 Sep 1;39(9):1263-72.
6. Vishwakarma A, Nikam P, Mogal R, Talele S. Review on nanosponges: A benefication for novel drug delivery. Int J PharmTech Res. 2014 Jan;6:11-20.
7. Singh D, Soni GC, Prajapati SK. Recent advances in nanosponges as drug delivery system: a review. Eur J Pharm Med Res. 2016;3(10):364-71.
8. Selvamuthukumar S, Anandam S, Krishnamoorthy K, Rajappan M. Nanosponges: A novel class of drug delivery system-review. Journal of Pharmacy & Pharmaceutical Sciences. 2012 Jan 17;15(1):103-11.
9. Trotta F, Dianzani C, Caldera F, Mognetti B, Cavalli R. The application of nanosponges to cancer drug delivery. Expert Opinion on Drug Delivery. 2014 Jun 1;11(6):931-41.
10. Geeta Aggarwal, Manju Nagpal and Gurpreet Kaur. Development and Comparison of Nanosponge and Niosome based Gel for the Topical Delivery of Tazarotene. Pharmaceutical Nanotechnology. 2016; (4):213-228
11. Prathima Srinivas, Sreeja K. Formulation and Evaluation of Voriconazole Loaded Nanosponges for Oral and Topical Delivery. International Journal of Drug Delivery & Research. 2013; 5(1):55-69.
12. Subhash Chandra Bose Penjuri, Nagaraju Ravouru, Saritha Damineni, Sailakshmi Bns and Srikanth Reddy Poreddy. Formulation and Evaluation of Lansoprazole Loaded Nanosponges. Turkish Journal of Pharmaceutical Sciences.2016; 13(3):304-310.
13. V. V. Pande, N. A. Kadnor, Rupali N. Kadam and S. A. Upadhye. Fabrication and Characterization of Sertaconazole Nitrate Microsponge as a Topical Drug Delivery System. Indian Journal of Pharmaceutical Sciences. 2015; 77(6):675-680.
14. Qurat-ul-ain Shoaib, Nasir Abbas, Muhammad Irfan, Amjad Hussain, Muhammad Sohail Arshad, Syed Zajif Hussain, Sumera Latif and Nadeem Irfan Bukhari. Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen. Tropical Journal of Pharmaceutical Research. 2018;17(8):1465-1474.
15. Anjali S. Kumar, Sheri P.S and M.A Kuriachan. Formulation and Evaluation of Antifungal Nanosponge Loaded Hydrogel for Topical Delivery. Journal of Pharmacy Practice and Research. 2018; 13(1): 362-379.
16. Swarupa Arvapally, M. Harini, G. Harshitha and A. Arunkumar. Formulation and In-vitro Evaluation of Glipizide Nanosponges. American Journal of Pharm tech Research. 2017; 7(3):2249-3387.
17. Higuchi T., Mechanism of sustained action medication: theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci.1963; 52: 1145–1148.
18. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm.1983; 15: 25–35.
19. Peppas, L. B., and Peppas, N. A. 1989. Solute and penetrant diffusion in swellablepolymers. IX. The mechanisms of drug release from pH-sensitive swelling-controlled systems.J. Control. Rel.8:267–274.