Volume : 09, Issue : 12, December – 2022
Title:
57.REVIEW OF DEXAMETHASONE AND PREDNISONE FOR ACUTE ASTHMA EXACERBATIONS IN PEDIATRIC PATIENTS
Authors :
Samar Awd Almjnony, Hasse Awd Almjnoony, Saeed Hamid Alsuhimi, Majed Mohammed Alassaf, Shaykhah Ghazi Alharbi, Ahmed Mohammed Alzhrani, Shatha Ibrahim Alfrasani
Abstract :
Asthma exacerbations are the main cause of hospitalizations among children. Corticosteroids are crucial for treating asthma exacerbations. The majority of current corticosteroid therapy regimens for hospitalized children with asthma exacerbation involve a 5-day course of prednisone or prednisolone. We searched electronic medical databases for all pertinent research published through the end of 2022. Systemic corticosteroids enhance the condition of hospitalized children with acute asthma. Among the potential benefits include an earlier discharge and fewer relapses. At this time, inhaled or nebulized corticosteroids cannot be recommended as an alternative to systemic steroids. Dexamethasone has been proposed as an alternative to prednisone/prednisolone for young children with acute asthma exacerbations
Cite This Article:
Please cite this article in press Samar Awd Almjnony et al, Review Of Dexamethasone And Prednisone For Acute Asthma Exacerbations In Pediatric Patients., Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
References:
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10. Gries DM, Moffitt DR, Pulos E, Carter ER. A single dose of intramuscularly administered dexamethasone acetate is as effective as oral prednisone to treat asthma exacerbations in young children. J Pediatr. (2000) 136:298–303. 10.1067/mpd.2000.103353
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16. Eigen H, Laughlin JJ, Homrighausen J. Recurrent pneumonia in children and its relationship to bronchial hyperreactivity. Pediatrics. 1982;70:698–704.
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21. Andrews AL, Wong KA, Heine D, et al.. A cost-effectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations. Acad Emerg Med 2012;19:943–8. 10.1111/j.1553-2712.2012.01418.x
22. Hames H, Seabrook JA, Matsui D, et al.. A palatability study of a flavored dexamethasone preparation versus prednisolone liquid in children. Can J Clin Pharmacol 2008;15:e95–e98.
23. Butler K, Cooper WO. Adherence of pediatric asthma patients with oral corticosteroid prescriptions following pediatric emergency department visit or hospitalization. Pediatr Emerg Care 2004;20:730–5. 10.1097/01.pec.0000144914.78124.6f
24. Scarfone RJ, Fuchs SM, Nager AL, et al. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics. 1993;92:513–8.
25. Rowe BH, Spooner C, Ducharme FM, et al. Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst Rev. 2001;(1):CD002178.
26. O’Driscoll BR, Kalra S, Wilson M, et al. Double-blind trial of steroid tapering in acute asthma. Lancet. 1993;341:324–7.
27. Qureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. 2001;139:20–6. [PubMed] [Google Scholar]
28. Altamimi S, Robertson G, Jastaniah W, et al. Single-dose oral dexamethasone in the emergency management of children with exacerbations of mild to moderate asthma. Pediatr Emerg Care. 2006;22:786–93.
29. Schuh S, Dick PT, Stephens D, et al. High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Pediatrics. 2006;118:644–50.
30. Schuh S, Reisman J, Alshehri M, et al. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med. 2000;343:689–94. \
31. Edmonds ML, Camargo CA, Jr, Pollack CV, Jr, et al. Early use of inhaled corticosteroids in the emergency department treatment of acute asthma. Cochrane Database Syst Rev. 2003;(3):CD002308.
32. Gorelick MH, Scribano PV, Stevens MW, Schultz TR. Construct validity and responsiveness of the Child Health Questionnaire in children with acute asthma. Ann Allergy Asthma Immunol 2003;90:622-8.
33. Macias CG, Caviness AC, Sockrider M, Brooks E, Kronfol R, Bartholomew LK, et al. The effect of acute and chronic asthma severity on pediatric emergency department utilization. Pediatrics 2006;117:S86- 95.
34. Lenhardt R, Catrambone CD, McDermott MF,Walter J,Williams SG,Weiss KB. Improving pediatric asthma care through surveillance: the Illinois emergency department asthma collaborative. Pediatrics 2006;117:S96- 105.
35. Klig JE, Hodge D III, Rutherford MW. Symptomatic improvement following emergency department management of asthma: a pilot study of intramuscular dexamethasone versus oral prednisone. J Asthma 1997;34:419-25.
2. Scarfone RJ, Friedlaender E. Corticosteroids in acute asthma: past, present, and future. Pediatr Emerg Care. 2003;19(5):355–361
3. Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980–2007. Pediatrics. 2009;123(suppl 3):S131–S145
4. Normansell R, Kew KM, Mansour G. Different oral corticosteroid regimens for acute asthma. Cochrane Database Syst Rev. (2016) CD011801. 10.1002/14651858.CD011801.pub2
5. Keeney GE, Gray MP, Morrison AK, Levas MN, Kessler EA, Hill GD, et al.. Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics. (2014) 133:493–9. 10.1542/peds.2013-2273
6. Schwarz ES, Cohn BG. Is dexamethasone as effective as prednisone or prednisolone in the management of pediatric asthma exacerbations? Ann Emerg Med. (2015) 65:81–2. 10.1016/j.annemergmed.2014.05.023
7. BTS/SIGN . British Guideline on the Management of Asthma. (2019). Available online at: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/asthma/
8. Qureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. (2001) 139:20–6. 10.1067/mpd.2001.115021
9. Butler K, Cooper WO. Adherence of pediatric asthma patients with oral corticosteroid prescriptions following pediatric emergency department visit or hospitalization. Pediatr Emerg Care. (2004) 20:730–5. 10.1097/01.pec.0000144914.78124.6f.
10. Gries DM, Moffitt DR, Pulos E, Carter ER. A single dose of intramuscularly administered dexamethasone acetate is as effective as oral prednisone to treat asthma exacerbations in young children. J Pediatr. (2000) 136:298–303. 10.1067/mpd.2000.103353
11. Klig JE, Hodge D, Rutherford MW. Symptomatic improvement following emergency department management of asthma: a pilot study of intramuscular dexamethasone versus oral prednisone. J Asthma. (1997) 34:419–25. 10.3109/02770909709055384
12. Cronin JJ, McCoy S, Kennedy U, An Fhailí SN, Wakai A, Hayden J, et al.. A randomized trial of single-dose oral dexamethasone versus multidose prednisolone for acute exacerbations of asthma in children who attend the emergency department. Ann Emerg Med. (2016) 67:593–601.e3. 10.1016/j.annemergmed.2015.08.001
13. Becker A, Bérubé D, Chad Z, et al. Canadian Pediatric Asthma Consensus Guidelines, 2003 (updated to December 2004): introduction. CMAJ. 2005;173(6 Suppl):S12–4.
14. To T, Dell S, Dick PT, et al. Case verification of children with asthma in Ontario. Pediatr Allergy Immunol. 2006;17:69–76.
15. Taussig LM, Smith SM, Blumenfeld R. Chronic bronchitis in childhood: what is it? Pediatrics. 1981;67:1–5.
16. Eigen H, Laughlin JJ, Homrighausen J. Recurrent pneumonia in children and its relationship to bronchial hyperreactivity. Pediatrics. 1982;70:698–704.
17. Herbert FA, Wilkinson D, Burchak E, et al. Adenovirus type 3 pneumonia causing lung damage in childhood. CMAJ. 1977;116:274–6.
18. Singleton R, Morris A, Redding G, et al. Bronchiectasis in Alaska Native children: causes and clinical courses. Pediatr Pulmonol. 2000;29:182–7.
19. Smith M, Iqbal S, Elliott TM, et al.. Corticosteroids for hospitalised children with acute asthma. Cochrane Database Syst Rev 2003;2:CD002886 10.1002/14651858.CD002886
20. Keeney GE, Gray MP, Morrison AK, et al.. Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics 2014;133:493–9. 10.1542/peds.2013-2273
21. Andrews AL, Wong KA, Heine D, et al.. A cost-effectiveness analysis of dexamethasone versus prednisone in pediatric acute asthma exacerbations. Acad Emerg Med 2012;19:943–8. 10.1111/j.1553-2712.2012.01418.x
22. Hames H, Seabrook JA, Matsui D, et al.. A palatability study of a flavored dexamethasone preparation versus prednisolone liquid in children. Can J Clin Pharmacol 2008;15:e95–e98.
23. Butler K, Cooper WO. Adherence of pediatric asthma patients with oral corticosteroid prescriptions following pediatric emergency department visit or hospitalization. Pediatr Emerg Care 2004;20:730–5. 10.1097/01.pec.0000144914.78124.6f
24. Scarfone RJ, Fuchs SM, Nager AL, et al. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics. 1993;92:513–8.
25. Rowe BH, Spooner C, Ducharme FM, et al. Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst Rev. 2001;(1):CD002178.
26. O’Driscoll BR, Kalra S, Wilson M, et al. Double-blind trial of steroid tapering in acute asthma. Lancet. 1993;341:324–7.
27. Qureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr. 2001;139:20–6. [PubMed] [Google Scholar]
28. Altamimi S, Robertson G, Jastaniah W, et al. Single-dose oral dexamethasone in the emergency management of children with exacerbations of mild to moderate asthma. Pediatr Emerg Care. 2006;22:786–93.
29. Schuh S, Dick PT, Stephens D, et al. High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Pediatrics. 2006;118:644–50.
30. Schuh S, Reisman J, Alshehri M, et al. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N Engl J Med. 2000;343:689–94. \
31. Edmonds ML, Camargo CA, Jr, Pollack CV, Jr, et al. Early use of inhaled corticosteroids in the emergency department treatment of acute asthma. Cochrane Database Syst Rev. 2003;(3):CD002308.
32. Gorelick MH, Scribano PV, Stevens MW, Schultz TR. Construct validity and responsiveness of the Child Health Questionnaire in children with acute asthma. Ann Allergy Asthma Immunol 2003;90:622-8.
33. Macias CG, Caviness AC, Sockrider M, Brooks E, Kronfol R, Bartholomew LK, et al. The effect of acute and chronic asthma severity on pediatric emergency department utilization. Pediatrics 2006;117:S86- 95.
34. Lenhardt R, Catrambone CD, McDermott MF,Walter J,Williams SG,Weiss KB. Improving pediatric asthma care through surveillance: the Illinois emergency department asthma collaborative. Pediatrics 2006;117:S96- 105.
35. Klig JE, Hodge D III, Rutherford MW. Symptomatic improvement following emergency department management of asthma: a pilot study of intramuscular dexamethasone versus oral prednisone. J Asthma 1997;34:419-25.