Volume : 09, Issue : 12, December – 2022
Title:
64.FORMULATION AND OPTIMIZATION OF MOUTH DISSOLVING TABLETS CONTAINING INDOMETHACIN SOLID DISPERSION
Authors :
H. Padmalatha
Abstract :
Oral drug delivery is the most widely used route of drug administration among all the routes that have been explored for the systemic delivery via various pharmaceutical products of different dosage forms. Aim of the present work is to formulate the indomethacin tablets to present it in the form of. To develop and over an extended period of time in the gastro intestinal track and compared the in-vitro dissolution profile with that of the marketed product. It was deduced that MDTs of Indomethacin formulated by direct compression method. The superdisintegrants were used in formulation to ameliorate the disintegration of tablets. It produces better patient compliance and effective therapy of tablets. Also, the bitter drug can be easily formulated as mouth dissolving tablets by masking their taste using aspartame as taste masking agent. It was also found that the superdisintegrants are effective at an optimum concentration, on increasing the ratio of Crospovidone and Sodium starch glycolate concentration above their optimum concentration this enhance the gelling effects of formulation. The formulation TC7 exhibited better results as compared to other formulations. Further these formulations can be select for in vivo study.
Key words: Formulation, Optimization, Mouth Dissolving Tablets, Indomethacin, Solid Dispersion
Cite This Article:
Please cite this article in press H. Padmalatha , Formulation And Optimization Of Mouth Dissolving Tablets Containing Indomethacin Solid Dispersion., Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
References:
2. Banker, GS., Anderson, N. R., 1987, Tablets, In: Lachman, L., Lieberman, H. A., Kanig, J. L. (Eds.), The Theory and Practice of Industrial Pharmacy, 3rd ed. Varghese Publishing House, Mumbai, pp. 327.
3. Barnhart, S. D., Sloboda, M. S., 2007, Dissolvable films the future of dissolvable films, Drug Dev. Tech., 1, 34- 35.
4. Bhalla, N., Deep, A., Goswami, M., 2012, An overview on various approaches oral controlled drug delivery system via gastro-retention drug delivery system, Int. Res. J. Pharm., 3, 128–33.
5. Bi, Y. X., Sunada, H., Yonezawa, Y., Danjo, K., 1999, Evaluation of rapidly disintegrating tablets prepared by a direct compression method, Drug Dev. Ind. Pharm., 25, 571– 581.
6. Cooper, J., Gunn, C., 1986, Powder flow and compaction. In: Carter, S. J. (Ed.), Tutorial Pharmacy, CBS Publishers and Distributors, New Delhi, India, pp. 211– 233.
7. Douroumis, D., 2007, Practical approaches of taste masking technologies in oral solid forms, Expert Opin. Drug Deliv., 4, 417– 426.
8. Elkhodairy, K. A., Hassan, M. A., Afifi, S.A., 2013, Formulation and optimization of orodispersible tablets of flutamide. Saudi Pharm. J. Article in Press,
9. Ghosh, T. K., Jasti, B. R., (Ed.), 2005, Theory and Practice of Contemporary Pharmaceutics, CRC press, pp. 282–367, 150–155.
10. Goto T., Tanidab, N., 2004, Pharmaceutical design of a novel colon-targeted delivery system using two-layer-coated tablets of three different pharmaceutical formulations, supported by clinical evidence in humans, J. Control. Release, 97, 31– 42.
11. Gryczke, A., Schminke, S., Maniruzzaman, M., Beck, J., Douroumis, D., 2011, Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion, Colloids and Surfaces B: Biointerfaces, 86, 275–284.
12. Guidance for Industry: Orally Disintegrating Tablets, Center for Drug Evaluation and Research (CDER) US FDA, Dec. 2008.
13. Habibh, W., Khankarik, R., Hontz, J., 2000, Fast-dissolve drug delivery system, Crit. Rev. Ther. Drug Carrier Syst., 17, 61–72.
14. Indian Pharmacopeia, Vol. II, 2010, The Government of India, Ministry of Health & Family welfare. The Indian Pharmacopeial commission, Ghaziabad, India, pp. 752-753.
15. Kottke, M. K., Rudnic, E. M., 2002, In: Rhodes CT., Banker GS., (Eds.), Modern Pharmaceutics, 4th ed, Mercel Dekker, INC. New York. Basel, PP. 299-300.
16. Krishnaiah, Y. S. R., Karthikeyan, R. S., Satyanarayana, V., 2002, A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate, Int. J. Pharm., 241, 353-366.
17. Kulmacz, RJ., 1989, Topography of prostaglandin H synthase. Antiinflammatory agents and the proteasesensitive arginine 253 region, J. Biol. Chem., 264, 14136–14144.
18. Martin, A., Bustamante, P., Chun, A., 2002, Micromeritics, In: Physical PharmacyPhysical Chemical Principles in the Pharmaceutical Sciences, 4th ed., Lippincott Williams and Wilkins, Baltimore, pp. 446–448
19. Peppas, NA., Buri, PA., 1985, Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, J. Control. Release, 2, 257–275.
20. Prabhu, P., Malli, R., Koland, M., Vijaynarayana, K., et al., 2011, Formulation and evaluation of fast dissolving films of levocitirizine dihydrochloride, Int. J. Pharm. Invest., 1, 99–104.
21. Saurabh, R., Malviya, R., Sharma, PK., 2011, Trends in buccal film: formulation characterization, recent studies and patents, Eur. J. Appl. Sci., 3, 93–101.