Volume : 09, Issue : 12, December – 2022
Title:
72.FORMULATION, CHARACTERIZATION AND EX-VIVO EVALUATION OF PRONIOSOMAL GEL OF PROGESTERONE FOR TRANSDERMAL DRUG DELIVERY SYSTEM
Authors :
Maneesha Palle and Shayeda*
Abstract :
The aim of the present work is to improve the bioavailability of progesterone by formulating in to Proniosomal gel for transdermal delivery. A Proniosomal gel was prepared by using various non- ionic surfactants (tweens and spans), lecithin, cholesterol & ethanol. Proniosomes were prepared by co-acervation phase separation and were evaluated. The optimized formulation (F1) showed mean globule size of 182.6 ± 5.24 nm, PDI 0.218 ± 0.043, Zeta potential -22 ± 1.12 (mV), drug content 98.8% entrapment efficiency 97.79%. The In- vitro drug release of F1 formulation showed significantly higher drug release was 76.61 ± 2.66% compared to drug suspension (8.56 ± 3.92%) and follows zero order kinetics and Higuchi’s model by Fickian diffusion. The ex-vivo permeation studies were carried out for formulation (F1) and drug suspension on rats’ abdominal skin. The theoretical flux was calculated that is (41.02µg/hr/cm2). Steady state flux value of optimized proniosomal gel formulation (67.08 ± 0.53µg/cm2/h) was significantly high compared to drug suspension (5.78 ± 0.55µg/cm2/h). The steady state flux of optimized proniosomal gel formulation F1 was 11.6 times to the flux of drug suspension.
Keywords: Progesterone, Proniosomal gel, Transdermal delivery, Permeation, Entrapment efficiency
Cite This Article:
Please cite this article in press Maneesha Palle et al, Formulation, Characterization And Ex-Vivo Evaluation Of Proniosomal Gel Of Progesterone For Transdermal Drug Delivery System.., Indo Am. J. P. Sci, 2022; 09(12).
Number of Downloads : 10
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