Volume : 09, Issue : 02, February – 2022
Title:
13.ENHANCEMENT OF SOLUBILITY AND DEVELOPMENT OF FAST DISSOLVING ORAL FILM OF ATORVASTATIN
Authors :
Vinod Kumar, Anwar Iqbal Khan, Dr Navjot Singh
Abstract :
Fast dissolving oral film are those when put on tongue disintegrate/dissolve/disperse instantaneously releasing the drug which dissolve or disperses in the saliva with Their characteristic advantages such as administration without water, anywhere, anytime lead to their suitability to geriatric and paediatric patients. Atorvastatin is prescribed to treatment of hypertension. Therefore, a new Atorvastatin calcium preparation that is useful for swallow function deficient patients is needed. Keeping an objective an attempt is made to develop fast dissolving oral film of Atorvastatin. The preliminary study showed that Atorvastatin is White to off-white and Odorless powder. It is freely soluble in methanol and ethanol and soluble in 0.1 N Hydrochloric acids, Phosphate buffer pH 6.8, and slightly soluble in water the melting point was in the range of 158-160 oC which is compliance with the standard value of as per Indian Pharmacopoeia. Identification of Atorvastatin was performed by UV/VIS Spectroscopy. The λmax of Atorvastatin was found to be 248nm. From the respective stock solution (1mg/ml) different concentration of 5, 10, 15, 20 and 25µg/ml Atorvastatin was prepared and scanned in UV region. Fast dissolving oral film oral film containing Atorvastatin were prepared using solvent casting method. The prepared Oral film was further evaluated for disintegration time, and uniformity of drug content, and In- vitro Release Studies. Percentage assay of different formulation was determined by U.V. vis Spectroscopy. The percentage assay of different formulation was in range of 95.23±0.65 to 99.56±0.58%. The maximum percentage assay (99.56±0.58%) and less disintegration time were found in formulation F6 in fast dissolving oral film. The optimized formulation of batch F6 subjected to further In vitro drug release.
Keywords: Optimization, Dosage form, Drug, Evaluation, Release
Cite This Article:
Please cite this article in press Vinod Kumar al, Enhancement Of Solubility And Development Of Fast Dissolving Oral Film Of Atorvastatin., Indo Am. J. P. Sci, 2022; 09(2).
Number of Downloads : 10
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