Volume : 09, Issue : 01, January – 2022



Authors :

Mahendra sahu, Anwar Iqbal khan and Dr. Navjot singh

Abstract :

The present study was to formulation and optimization of fast dissolving tablet of terbutaline sulphate by novel co-processing, Terbutaline sulphate tablets containing co-processed superdisintegrants exhibited quick disintegration and improved drug dissolution. This formulation is more cost effective than aerosol inhalation pumps available. It was found that the total maximum amount of drug from the optimised batch was released in first 4 minutes of the dissolution study. The tablets disintegrated within 50 sec under experimental in vitro laboratory conditions. It can be concluded from the present work that co-processed superdisintegrants of crospovidone and croscarmellose are superior to physical mixture of crospovidone and croscarmellose used in Terbutaline sulphate fast dissolving tablets.
Keywords: Superdisintegrants, co-processing, disintegration time, excipients, capillary

Cite This Article:

Please cite this article in press Mahendra sahu et al, Formulation And Optimization Of Fast Dissolving Tablet Of Terbutaline Sulphate By Novel Co-Processing., Indo Am. J. P. Sci, 2022; 09(01).

Number of Downloads : 10


1. Aithal KS, Nalini K, Udupa N and Sreenivasan KK. Enhanced fluorescence emission of norfloxacin on complexation with cyclodextrin. Indian Drugs, 2005; 42(3): 162-166.
2. Allen, LV. And Wang, B. 2001. Process for making a particulate support matrix for making a rapidly dissolving dosage form. US Patent 6207199.
3. Ammanage A., et al ; Taste Masking of Dicyclomine Hydrochloride by Polymer Carrier System and Formulation of Oral Disintegrating Tablets; Asian J Pharm Clin Res, 2011, 4(1), 35-40
4. Anand, Vikas., kataria, Mahesh., kukkar Vipin., Saharan, Vandana. and Choudhary, Kumar. Pratim. 2007. The latest Trends in the taste assessment of pharmaceuticals. Drug discovery today. 12(5/6): 257-265.
5. Anand,Vikas., Kharab,Vandana., Kataria, Mahesh., Kukkar, Vipin. and Choudhary, Kumar. Pratim. Taste assessment trials for sensory analysis of oral pharmaceutical products. Pak. J. Pharm. Sci., 2008; 21(4): 438-450.
6. Ashtamkar J.P., et al, formulation development of fast dissolving nabumetone tablets, D Dev Ind Pharm, 2003; 17(4); 112-116
7. Baboota S., Al-Azaki A., Kohli K., Ali J., Dixit N., Shakeel F., Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine PDA. J. Pharm. Sci. Technol., 2007 61; 276–285.
8. Badwana A.A., Khordaguib L.K., Saleh A.M., Khalil, S.A., The solubility of benzodiazepines in sodium salicylate solution and a proposed mechanism for hydrotropic solubilization. International journal of Pharmaceutics, 1982; 13(1); 67-74.
9. Bakan, J. A., Microencapsulation, Theory and practice of industrial pharmacy., 1986; 3:412- 429.
10. Balasubramanian D., Friberg, S. E., In Surface and Colloid Science (ed. Matijevic, E.), Plenum Press, New York, 1993; 15; 197-220.
11. Baroli B., Lopez-Quintela M.A., Delgado-Charro M.B., Fadda A.M., Blanco-Mendez J., Microemulsions for topical delivery of 8-methoxsalen. J. Control Release, 2000; 69; 209– 218.
12. Belgamwar VS et al. Studies on occlusion complexes of Furazolidine with cyclodextrins and their hydroxypropyl derivatives. Indian Drugs, 2001; 38(9): 479-482.
13. Belgumwar VS et al. Development and evaluation of occlusion complexes of griseofulvin with cyclodextrins and hydroxypropyl derivatives. Indian Drugs, 2002; 39(3): 158-160.
14. Bergeson L. L., Cole M. F. (2006). NanoBioConvergence—Emerging Diagnostic and Therapeutic Applications. Bioprocessing and Biopartnering: Featuring NanoBiotechnology.