Volume : 09, Issue : 01, January – 2022
07.FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF CHLORZOXAZONE USING DIFFERENT FILM FORMING AGENTS
Sanno*, Rahul Sharma, Dr. Jagdish Chandra Rathi
Muscle spasm needs prompt relief of symptoms. Chlorzoxazone is a centrally muscle relaxant. Which are having shorter half life (1.1hour) with the dose administration of 3-4 times a day. Oral film of chlorzoxazone quickly disintegrates and dissolves and can be administered without water, making them particularly suitable for geriatric patients and found faster action. Fast dissolving oral films (FDOFs) have gained popularity not only in breath strips but also in personal care, food drug delivery markets. The aim of present work is to formulate and evaluate fast dissolving oral films of chlorzoxazone to improve water solubility, dissolution rate, oral bioavailability and reduction of first pass metabolism and increase patient’s compliance. Oral fast dissolving films prepared by solvent casting method using water and 95% ethanol as solvents and gelatin, xanthan gum, gum acacia as film forming polymer. Superdisintegrants such as croscarmellose sodium (CCS) was incorporated to achieve the aim. The prepared films were evaluated for the drug content, weight variation, film thickness, folding endurance, disintegration time, percentage of moisture content and in vitro dissolution studies and taste mask studies on healthy human volunteers. Among all, the formulation F6 was found to be best formulation which releases 98.85±0.25% of the drug within 360sec and disintegration time is 10±5sec. which was significantly high when compared to other formulation.
Keywords: Chlorzoxazone, Fast dissolving oral film, Bioavailability, Mechanical properties
Cite This Article:
Please cite this article in press Sanno et al, Formulation And Evaluation Of Fast Dissolving Oral Film Of Chlorzoxazone Using Different Film Forming Agents., Indo Am. J. P. Sci, 2022; 09(01).
Number of Downloads : 10
1. Liang AC, Chen LH. Fast‑dissolving intraoral drug delivery systems. Exp Opin Ther Patents 2001;11:981–6.
2. Borsadia S, O’Halloran D, Osborne JL. Quick dissolving films‑A novel approach to drug delivery. Drug Deliv Technol 2003;3:63‑6.
3. Dixit RP, Puthli SP, Oral strip technology: Overview and future potential, J Cont Rel 139, 94-107, 2009.
4. Vollmer U, Galfetti P, Rapid film: Oral thin films as an innovative drug delivery system and dosage form, Drug Dev Report 64-67, 2006.
5. Klancke J. Dissolution testing of orally disintegrating tablets. Dissolut Technol 2003;10:6–8.
6. Parakh SR, Gothoskar AV. Review of mouth dissolving tablettechnologies. Pharm Tech 2003; 27:92–100.
7. Kunte S, Tandale P, Fast dissolving strips: a novel approach for the delivery of verapamil, J Pharm Bioallied Sci 2(4), 325-328, 2010.
8. Gautam SP, Rai JP, Billshaiya U, Jain N, Vikram P, Jain DK. Formulation and evaluation of mouth dissolving tablet of loperamide. Int J Pharm Sci Res. 2013; 4(5): 1782-1788.
9. Sushma M, Prasanna YR, Sundaresan C, Vandana K, Kumar NV, Chowdary VH, Transmucosal delivery of metformin- A comprehensive study, Curr Drug Deliv July, 2013. PMID: 23848354.
10. Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukioka T, Yamashita H, Inagaki N, Hirano K, Yamamoto M, Kinosada Y, Itoh Y, Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to anti-emesis during cancer chemotherapy, Eur J Pharm Biopharm 73(3), 361-365, 2009.
11. Prabhu P, Malli R, Koland M, Vijaynarayana K, D’Souza U, Harish N, Shastry C, Charyulu R, Formulation and evaluation of fast dissolving films of levocitirizine dihydrochloride, Int J Pharm Inv 1(2), 99-104, 2011.
12. Sweetman SC, Pharm B, PharmS FR. (2009). Martindale: the complete drug reference. 36th ed. London, UK: The Pharmaceutical Press, an imprint of RPS Publishing.
13. Chou R, Peterson K.Helfand M. (2004). Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage 28:140–75.
14. Florey K, Al-Badr AA, Brenner Gerald S. (1987). Analytical profiles of drug substances. London: Academic Press Inc., 137.
15. Xu WJ, Xie H-J, Cao QR, et al (2014). Enhanced dissolution and oral bioavailability of valsartan solid dispersions prepared by a freezedrying technique using hydrophilic polymers. Drug Deliv 23:41–8.
16. K. Senthilkumar and C. Vijaya. Formulation development of mouth dissolving film of etoricoxib for pain management. Advances in Pharmaceutics. 2015, Article ID 702963,.
17. Kumar GV, Krishna RV, William GJ, Konde A. Formulation and evaluation of buccal films of Salbutamol sulphate. Ind J Pharm Sci 2005; 67: 160–164.
18. Mona Nagar, Mayank Nagar and Vikram Chopra, Formulation and evaluation of mouth dissolving film of antipsychotic drug aripiprazole, Der Pharm Lett 2012; 4 (4): 1221- 1227.
19. Prabhu P, Malli R, Koland M, Vijaynarayana K, D’Souza U, Harish NM, Shastry CS. Formulation and evaluation of fast dissolving films of levocetrizine dihydrochloride, Int J Pharm Inves 2011;1(2): 99–104. 17.
20. Patel P, Rai JP, Jain DK, Banweer J. Formulation, development and evaluation of cefaclor extended release matrix tablet. Int J Pharm Pharm Sci 2012; 4(4): 355-357.
21. Nafee NA, Boraie MA, Ismail FA, Mortada LM. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. ACTA Pharm 2003; 53: 199–212.