Volume : 09, Issue : 01, January – 2022
Title:
15.DESIGN AND EVALUATION OF CLOZAPINE ORODISPERSIBLE TABLETS
Authors :
V. Rajesh Babu, Suresh Kumar Dev and Khaja Pasha
Abstract :
In the present investigation, Orodispersible tablets of Clozapine were prepared by direct compression method using Ac-di-sol and Crospovidone as superdisintegrants with various concentrations (2%, 4%, 6% and 8%). The drug and excipient blend was evaluated for bulk density, tapped density, carr’s index, angle of repose and hausner’s ratio. The prepared tablets were evaluated for hardness, thickness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time and dissolution studies. Among all the formulations, formulation containing crospovidone (F8) with the concentration of 8% produced less in vitro dispersion time ( 15 sec), disintegration time (19 sec), wetting time ( 17 sec) and higher drug release rate (94 %) in 30 minutes. Short-term stability studies on the promising formulations indicated that there are no significant changes in drug content and in vitro dispersion time. IR-spectroscopic studies indicated that there are no drug-excipient interactions.
Keywords: Clozapine, Ac-di-sol, Crospovidone, Orodispersible tablets.
Cite This Article:
Please cite this article in press V. Rajesh Babu et al Design And Evaluation Of Clozapine Orodispersible Tablets., Indo Am. J. P. Sci, 2022; 09(01).
Number of Downloads : 10
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