Volume : 09, Issue : 07, July – 2022



Authors :

Shivam Tiwari*, Mr. Amit Dubey, Mr. Prabhat Kumar Jain, Prashant Maithel, Dr. Sailesh Kumar Ghatuary

Abstract :

Floating drug delivery offers several applications for drugs having poor bioavailability because of the narrow absorption window in the upper part of the gastrointestinal tract. It retains the dosage form at the site of absorption and thus enhances the bioavailability. Flurbiprofen is a newer derivative NSAID, having short half-life of 2-4 hr, which required multiple daily doses to maintain the effective drug concentration. The long oral use of FP conventional dosage forms pronounced the drug gastro-intestinal adverse effects highly. Thus, Flurbiprofen was selected as a model drug for NSAIDs which is good candidate to be developed in sustained- release formulation. Aim of present work to develop sustained released tablets of
flurbiprofen using some novel synthetic and natural polymers. The % drug content of all the formulated tablets were found within the limit. % drug content value of Flurbiprofen was within 98.65±0.14% to 99.45±0.15%.The results within the range indicate uniform of mixing. Optimized formulation (F7) showed the release of drug form gastroretentive formulation 99.45% after 12 hrs. and marketed formulation showed the release of 95.65% after 1.5 hrs. When the regression coefficient values of were compared, it was observed that ‘r2’ values of first order was maximum i.e. 0.972 hence indicating drug release from formulations was found to follow first order release kinetics.
Key words: Flurbiprofen, Gastroretentive drug delivery system, Suatain release tablets, formulation, evaluation

Cite This Article:

Please cite this article in press Shivam Tiwari et al, Formulation And Evaluation Of Floating Tablets Of Flurbiprofen Using Some Novel Natural And Synthetic Polymers., Indo Am. J. P. Sci, 2022; 09(7).,

Number of Downloads : 10


1. Yale P.G., Khan S, Patel VF, Floating Drug Delivery Systems: Need and Development, Indian Journal of Pharmaceutical Sciences, 2005, 67, 265272.
2. Aterman KC, A Critical Review of Gastro retentive Controlled Drug Delivery, Pharmaceutical Development and Technology, 2007, 12, 1-10
3. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv 2006; 3(2): 217-33.
4. Rouge, N., Buri, P. A., and Doelker, E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int. J. Pharm. 136:115–122, 1996.
5. Iannucelli V, Coppi G, Bernabei MT, Camerorni R. Air compertment multiple-unit system for prolonged gastric residence. Part-I. Formulation study. Int J Pharm 1998; 174: 47-54.
6. D. Saritha, D. Sathish and Y. Madhusudan Rao. Formulation and evaluation of gastroretentive floating tablets of domperidone maleate. Journal of Applied Pharmaceutical Science 02 (03); 2012: 68-73.
7. Patel Amit, Jha Sajal Kumar, Panchal Harishanker, Shukla Tarkeshwar, Shah Arpit. Formulation development and evaluation of famotidine floating tablet. International journal of pharmaceutical sciences review and research. 2010; 4(3):224-29.
8. Chaudhri PD, Chaudhri SP, Kolhe SR. Formulation and evaluation of fast dissolving tablets of Famotidin. Indian Drugs. 2005; 42, 641-647.
9. Kumar R, Patil MB, Patil SR, Paschapur MS. “Formulation and Evaluation of Effervescent floating tablet of Famotidine”, Int J Pharm Tech Res, 2009; 1(3); 754-763.
10. Rosa M., Zia H., Rhodes T. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. Int. J. Pharm. 1994; 105:65–70.
11. Shishu G, Gupta N, Aggarwal N. A gastro-retentive floating delivery system for 5-fluorouracil. Asian J Pharm Sci 2007; 2: 143-49.