Volume : 09, Issue : 07, July – 2022
Title:
12.TO DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY
Authors :
Dr. Bharat .V. Jain, Drx. Kajal Vipin Jain *, Dr. Sandip. R. Pawar, Mr. Tanveer .Y. Shaikh
Abstract :
In-situ Gel for ocular drug delivery is prepares by using mucoadhesive polymers to increase ocular residence time and minimize precorneal drugs loss of given formulation. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition like Environmental PH, temperature, & ionic strength. In response to environmental changes, installed liquid in-situ rapidly undergoes gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result.
KEYWORDS- In-situ Gelling System, Ketorolac Tromethamine, Sodium Alginate, HPMC K4M, Benzalkonium Chloride,
Cite This Article:
Please cite this article in press Bharat .V. Jain et al, To Design, Development And Characterization Of Novel In Situ Gel For Ocular Drug Delivery., Indo Am. J. P. Sci, 2022; 09(7).,
Number of Downloads : 10
References:
1. Patel H, Desai D, Koradia S, Prajapati D. Role of In-situ Gel in Drug Delivery System: A Comprehensive Review. Journal of Advancement in Pharmacology.;1(2).
2. Suisha F, Kawasaki N, Miyazaki S, Shirakawa M, Yamatoya K, Sasaki M, Attwood D. Xyloglucan gels as sustained release vehicles for the intraperitoneal administration of mitomycin C. International journal of pharmaceutics. 1998 Oct 15;172(1-2):27-32.
3. Miyazaki S, Endo K, Kawasaki N, Kubo W, Watanabe H, Attwood D. Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. Drug development and industrial pharmacy. 2003 Jan 1;29(2):113-9.
4. Mohanty D, Bakshi V, Simharaju N, Haque MA, Sahoo CK. A review on in situ gel: a novel drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2018;50(1):175-81.
5. Saraswat R, Bhan CS, Gaur A. A review on polymers used in in-situ gel drug delivery systems. Int J Pharm Innov. 2011;1(2):110-8.
6. Liu Z, Li J, Nie S, Liu H, Ding P, Pan W. Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin. International journal of pharmaceutics. 2006 Jun 6;315(1-2):12-7.
7. Edsman K, Carlfors J, Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. European journal of pharmaceutical sciences. 1998 Apr 1;6(2):105-12.
8. Gurny R, Ibrahim H, Buri P. The development and use of in situ formed gels triggered by pH-in biopharmaceutics of ocular drug delivery. Edman, PCrs Press199381-90. 1993.
9. Cohen S, Lobel E, Trevgoda A, Peled Y. A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. Journal of controlled release. 1997 Feb 17;44(2-3):201-8.
10. Mandal S, Thimmisetty M. K., Prabhushankar G. L., Geetha M.S..: Formulation and evaluation of an in-situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride. Int J PharmaInvesting2012: Vol 2(2),78-82.
11. Gupta H.,Jain S., Mathur R., Mishra P., Mishra A.K.&VelpandianT., Sustained Ocular Drug Delivery from a Temperature and pH Triggered Novel in Situ Gel System, Drug Delivery, 2007: Vol 14(8), 507-515.
12. Vodithala S., Khatary S., ShastriN., Sadhanam M., Formulation and Evaluation of Ion activated Insitu Gel of Ketorolac,IntranationalGournalof Current Pharmaceutical Reserch2010 :Vol 2,(3) 33-38.
13. S. Deepthi. Jobin Jose; Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis; Int Ophthalmol (2019) 39:1355–1366.