Volume : 09, Issue : 07, July – 2022
18.IN VIVO ANTIHYPERLIPIDEMIC EFFECTS OF LEAF EXTRACT OF TRICHOSANTHES CUCUMERINA
Mohammad Waseem, Balweer Singh Kirar, Dr. Alok Pal Jain
The objective of the present research work was to investigate the antioxidant and antihyperlipidemic activity of extract of leaves of Trichosanthescucumerina in vivo effects on High Fat diet induced hyperlipidemia respectively. Animals were divided into different groups. Briefly, the normal group received a standard chow diet and all other groups received a high-cholesterol diet consisting of normal chow diet 92%, cholesterol 2%, cholic acid 1%, and coconut oil 5% for 7 days. The reference drug (Atorvastatin 50 mg/kg) and extracts were administered once daily between 8:00 and 9:00 a.m. for 7 days. The daily food intakes were determined before treatments.There was a significant increase in the serum levels of TC, TG, LDL-C, VLDL-C, and HDL-C in the hyperlipidimic control group as compared with the normal control group. All the treatment groups produced a significant decrease in serum TC, TG, HDL-C, and VLDL-C levels. In addition to the above, the serum LDL-C levels were significantly decreased by the Trichosanthescucumerina leaves extracts. In the present study, we have selected the Ethanolic extracts Trichosanthescucumerina leaves have shown significant antioxidant activity. By the virtue of its antioxidant activity, Trichosanthescucumerina leaves show antihyperlipidemic activity.
Key words:Trichosanthes cucumerina, Antihyperlipidemic, antioxidant, High Fat diet induced.
Cite This Article:
Please cite this article in press Balweer Singh Kirar et al,In Vivo Antihyperlipidemic Effects Of Leaf Extract Of Trichosanthes Cucumerina,Indo Am. J. P. Sci, 2022; 09(7).,
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