Volume : 09, Issue : 07, July – 2022



Authors :

Rishikesh Choudhary, Balweer Singh Kirar, Dr. Alok Pal Jain

Abstract :

Preventive and therapeutic activities of Hydroalcoholic extract of Talinum triangulare leaves against ethanol-induced ulcer in wistar rats is the aim of this study. Fresh plants of T. triangulare were purchased from a local market in Bhopal,M.P and were identified by a botanist. The extraction was done using Soxhlet apparatus and (Ethanol: water; 80:20) as the solvent. The process was allowed to run for a total of 18 hours. Five groups (n = 6) of Wistar rats were used to study the anti-ulcer activity of Talinum triangulare Hydroalcoholic extract. PBS, Hydroalcoholic extract, omeprazole and ethanol were administered to the animals per orally (p.o). Group 1 received PBS (10 mL/ kg) all over the experimental period (11 days) and served as control. Group 2 received PBS (10 mL/ kg) for 10 days and on the 11th day received absolute ethanol (5 mL/ kg) and served as ulcer control. Group 3 and 4 were respectively administered with 300 and 400 mg/kg Talinum triangulare Hydroalcoholic extract, group 5 with omeprazole (8 mg /kg) for 10 days. All the groups were fasted for 24 h and again administered with the extract or drug at respective dose. After 30 min of this treatment, animals of groups 2-5 were administered with 5 mL/ kg ethanol to induce ulcer. After 15 min of ethanol administration, all the animals were sacrificed using anesthetic ether. Gastric volume was measured by pylorus ligation method. Each stomach was opened along the greater curvature and examined macroscopically for gastric erosions under a dissecting microscope (20 X). The length and width (mm) of ulcer on the gastric mucosa were measured by plane glass square (10×10 mm).
Key words: Anti-ulcer Activity, Talinum triangulare, Pylorus ligation method

Cite This Article:

Please cite this article in press Balweer Singh Kirar et al,Evaluation Of Anti-Ulcer Activity Of The Extract Of Talinum Triangulare In Rats.,Indo Am. J. P. Sci, 2022; 09(7).,

Number of Downloads : 10


1. Lieber CS. Ethnic and gender differences in ethanol metabolism, Alcohol. Clin. Exp. Res. 2000;24 (4):417–418.
2. Wu D, Cederbaum AI. Alcohol, oxidative stress, and free radical damage, Alcohol Res. Health. 2003;27:277–284.
3. Nadro MS, Arungbemi RM, Dahiru D. Evaluation of Moringa oleifera leaf extract on alcohol-induced hepatotoxicity, Trop. J. Pharm. Res. 2007;5(1):539–544.
4. Das SK, Vasudevan DM. Alcohol-induced oxidative stress, Life Sci. 2007;81 (3):177–187.
5. Rahman T, Hosen I, Islam MT, Shekhar HU. Oxidative stress and human health. Adv Biosci Biotechnol. 2012;3:997–1019.
6. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4:118–126.
7. Morales-González JA. Oxidative Stress and Chronic Degenerative Diseases—A Role for Antioxidants, InTech, Rijeka, Croatia, 2013, pp. 500.
8. Airaodion AI, Olayeri IM, Ewa AO, Ogbuagu EO, Ogbuagu U, Akinmolayan JD, Agunbiade AP, Oloruntoba AP, Airaodion EO, Adeniji AR, Obajimi OO, Awosanya OO. Evaluation of Moringa oleifera Leaf Potential in the Prevention of Peptic Ulcer in Wistar Rats. International Journal of Research. 2019;6(2):579-584.
9. Airaodion AI, Adekale OA, Airaodion EO, Ogbuagu EO, Ogbuagu U, Osemwowa EU. Efficacy of Combined Extract of Curcuma longa and Moringa oleifera leaf in the Prevention of Peptic Ulcer in Albino Rats. Asian Journal of Research in Medical and Pharmaceutical Sciences. 2019;7(2):1-8.
10. Mbang A, Owolabi S, Jaja O, Opeyemi JO. Evaluation of the antioxidant activity and lipid peroxidation of the leaves of Vernonia amygdalina. J Complem Integ Med 5. 2008.
11. Airaodion AI, Adeniji AR, Ogbuagu EO, Ogbuagu U, Agunbiade AP. Hypoglycemic and hypolipidaemic activities of methanolic extract of Talinum triangulare leaves in Wistar rats. International Journal of Bio-Science and BioTechnology. 2019;11(5):1-13
12. Anoop, A. and Jegadeesan, M., 2003. Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R. Br. var. indicus. Journal of ethnopharmacology, 84(2-3), pp.149-156..
13. Classics Lowry, O., Rosebrough, N., Farr, A. and Randall, R., 1951. Protein measurement with the Folin phenol reagent. J biol Chem, 193(1), pp.265-75.
14. Mecozzi, M., 2005. Estimation of total carbohydrate amount in environmental samples by the phenol–sulphuric acid method assisted by multivariate calibration. Chemometrics and Intelligent Laboratory Systems, 79(1-2), pp.84-90.
15. Evans, D.A.P., 1960. The estimation of fucose in saliva. The Journal of Laboratory and Clinical Medicine, 55(3), pp.381-385.
16. Swift, M.J., 1973. The estimation of mycelial biomass by determination of the hexosamine content of wood tissue decayed by fungi. Soil Biology and Biochemistry, 5(3), pp.321-332.
17. Jourdian, G.W., Dean, L. and Roseman, S., 1971. The sialic acids: XI. A periodate-resorcinol method for the quantitative estimation of free sialic acids and their glycosides. Journal of Biological Chemistry, 246(2), pp.430-435.