Volume : 09, Issue : 07, July – 2022



Authors :

Dr. Bharat .V. Jain, Drx. Kajal Vipin Jain*, Dr. Sandip. R. Pawar, Mr. Tanveer.Y. Shaikh

Abstract :

Introduction: Overweight and obesity considered as one of the main predisposing health factors globally and contributed to The traditional dosage form has many limitations due to factors such as naso-lacrimal drainage & shorter contact time. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition. Environmental pH, temperature, & ionic strength, Response to environmental changes, the in- situ are liquids when installation into the eyes and then undergo rapidly gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result. The goal of this study is to prepare and evaluate In- situ Gel for ocular drug delivery by using mucoadhesive polymers to increase ocular residence time and minimize Precorneal drugs loss of given formulation.
Keywords: Ocular Drug Delivery, In-situ Gelling System, Conjunctivitis.

Cite This Article:

Please cite this article in press Kajal Vipin Jain et al, Review Of Novel In Situ Gel For Ocular Drug Delivery., Indo Am. J. P. Sci, 2022; 09(7).,

Number of Downloads : 10


1. Patel H, Desai D, Koradia S, Prajapati D. Role of In-situ Gel in Drug Delivery System: A Comprehensive Review. Journal of Advancement in Pharmacology.;1(2).
2. Suisha F, Kawasaki N, Miyazaki S, Shirakawa M, Yamatoya K, Sasaki M, Attwood D. Xyloglucan gels as sustained release vehicles for the intraperitoneal administration of mitomycin C. International journal of pharmaceutics. 1998 Oct 15;172(1-2):27-32.
3. Miyazaki S, Endo K, Kawasaki N, Kubo W, Watanabe H, Attwood D. Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. Drug development and industrial pharmacy. 2003 Jan 1;29(2):113-9.
4. Mohanty D, Bakshi V, Simharaju N, Haque MA, Sahoo CK. A review on in situ gel: a novel drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2018;50(1):175-81.
5. Saraswat R, Bhan CS, Gaur A. A review on polymers used in in-situ gel drug delivery systems. Int J Pharm Innov. 2011;1(2):110-8.
6. Liu Z, Li J, Nie S, Liu H, Ding P, Pan W. Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin. International journal of pharmaceutics. 2006 Jun 6;315(1-2):12-7.
7. Edsman K, Carlfors J, Petersson R. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. European journal of pharmaceutical sciences. 1998 Apr 1;6(2):105-12.
8. Gurny R, Ibrahim H, Buri P. The development and use of in situ formed gels triggered by pH-in biopharmaceutics of ocular drug delivery. Edman, PCrs Press199381-90. 1993.
9. Cohen S, Lobel E, Trevgoda A, Peled Y. A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. Journal of controlled release. 1997 Feb 17;44(2-3):201-8.
10. Mandal S, Thimmisetty M. K., Prabhushankar G. L., Geetha M.S..: Formulation and evaluation of an in-situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride. Int J PharmaInvesting2012: Vol 2(2),78-82.
11. Gupta H.,Jain S., Mathur R., Mishra P., Mishra A.K.&VelpandianT., Sustained Ocular Drug Delivery from a Temperature and pH Triggered Novel in Situ Gel System, Drug Delivery, 2007: Vol 14(8), 507-515.
12. Vodithala S., Khatary S., ShastriN., Sadhanam M., Formulation and Evaluation of Ion activated Insitu Gel of Ketorolac,IntranationalGournalof Current Pharmaceutical Reserch2010 :Vol 2,(3) 33-38.
13. S. Deepthi . Jobin Jose; Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis; Int Ophthalmol (2019) 39:1355–1366.
14. Mathews R, Rao Bp, Abbulu Konde Ss, Nawres A, Suresh C. Statistical Design And Development Of A Liquid Oral Floating In Situ Gel Of Metformin Hydrochloride For Sustained Release: Pharmacodynamic And Toxicity (Histopathology) Studies. Int J App Pharm. 2019;11(5):96-104.
16. Kubo W, Konno Y, Miyazaki S, Attwood D. In situ gelling pectin formulations for oral sustained delivery of paracetamol. Drug development and industrial pharmacy. 2004 Jan 1;30(6):593-9.
17. Carlfors J, Edsman K, Petersson R, Jörnving K. Rheological evaluation of Gelrite® in situ gels for ophthalmic use. European journal of pharmaceutical sciences. 1998 Apr 1;6(2):113-9.
18. Parekh HB, Jivani R, Jivani NP, Patel LD, Makwana A, Sameja K. Novel in situ polymeric drug delivery system: a review. Journal of Drug Delivery and Therapeutics. 2012 Sep 15;2(5)
19. Neha K, Nirmala HS. Insitu gelling system: A Review. J Drug Del and Therapeutics. 2014;4(4):93-103.
20. Jain S, Jain P, Mishra A, Pathak A. A Review on Triggered Gel for Ocular Drug Delivery.
21. Mali MN, Hajare AA. In situ gel-forming systems for sustained ocular drug delivery. European Industrial Pharmacy. 2010 Feb;5:17-20.