Volume : 09, Issue : 06, June – 2022
Title:
03.FORMULATION AND EVALUATION OF PIOGLITAZONE SUSTAINED RELEASE TABLET
Authors :
Shilpee Rai, Mr. Rupesh Jain, Mr. Pushpendra Kumar Khangar, Dr. Vivek Jain
Abstract :
A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. The matrix tablets were prepared by wet granulation method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Four formulations of different polymer percentages were formulated, (F1-F4).The formulated tablets were characterized by hardness, friability, thickness, weight variation and in vitro drug release. The formulated tablets had acceptable physicochemical characters. The quantity of pioglitazone present in the tablets and the release medium were estimated by a simple, rapid and validated UV method. The dissolution results show that increased amount of polymer resulted in reduced and extended drug release. This formulation may provide an alternative for oral controlled delivery of pioglitazone and be helpful in the future treatment of primary normoreactive types of inflammation.
Keywords: Ibuprofen, HPMC, Wet granulation method, Dissolution
Cite This Article:
Please cite this article in pressShilpi Raiet al,Formulation And Evaluation Of Pioglitazone Sustained Release Tablet.,Indo Am. J. P. Sci, 2022; 09(6).,
Number of Downloads : 10
References:
1. Advanced oral and parenteral drug delivery technologies: Players, products & prospects to 2015. Dublin: Espicom Business Intelligence Ltd, 2011.
2. Charman, S.A.; Charman, W. Oral modified-release delivery systems. In: Rathbone, M.J.; Hadgraft, J.; Roberts, M.S. (Eds.). Modified-release drug delivery technology. New York: Marcel Dekker, 2002. chap. 1.
3. Moodley, K.; Pillary, V.; Choonara, Y.E.; Toit, L.C.; Ndesendo, V.M.K.; Kumar, P.; Coopan, S. and Bawa, P. Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery. Int. J. Mol. Sci., v.13, p.18-43, 2012.
4. Malmsten, M. Surfactants and polymers in drug delivery. Stockholm: Marcel Dekker, 2002. 335p.
5. Qiu, L.Y.; Bae, Y.H. Polymer architecture and drug delivery. Pharmac. Res., v.23, n.1, p.1-30, 2006.
6. Fukuda, M.; Peppas, N.A.; McGinity, J.W. Properties of sustainedrelease hot-melt extruded tablets containing chitosan and xanthan gum. Int.J. Pharm., 2006, 310, 90-100.
7. Damien, G.; Barochez, B.H.; Schiavi, P. Galenic development and pharmacokinetic profile of indapamide sustained release 1.5 mg. Clin. Pharmacokinet., 1999, 1, 13-19.
8. Gil, E.C.; Colarte, A.I.; Bataille, B.; Pedraz, J.L.; Rodrigez, F.; Heinamaki, J. Development and optimization of a novel sustainedrelease dextran tablet formulation for propranolol hydrochloride. Int. J. Pharm., 2006, 317(1), 32-39.
9. Lopez, C.M.; Lobo, J.M.S.; Pinto, J.F.; Costa, P. Compressed minitablets as a biphasic delivery system. Int. J. Pharm., 2006, 323, 93- 100.
10. Varshosaz, J.; Tavakoli, N.; Eram, S.A. Use of natural gums and cellulose derivatives in production of sustained release metoprolol tablets. Drug Del., 2006, 13(2), 113-119.
11. Theodore WR, Alan SN, Taylor P, Gilman AG, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 8th ed, New York, NY: McGraw-Hill; 1991; pp1484
12. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 8th ed. New York, NY: McGraw-Hill; 1991: pp 1712.
13. Boudreau MD, Beland FA, An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe barbadensis Miller, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2006, 24 (1); 103–54.
14. Sreeramulu J, Hima Bindu V, Kumar CS, Kumar Reddy BK, “Fabrication and Evaluation of Glipizide Aloe barbadensis miller Leaf Mucilage Polyvinylpyrolidone Controlled Release Matrix Tablets” Journal of Pharmacy Research, 2010; 3(7):1569-1572
15. Kavitha K, Puneeth KP, Tamizh MT, “Development And Evaluation Of Rosiglitazone Maleate Floating Tablets” International Journal of Applied Pharmaceutics 2010; Vol 2 (2).
16. Wakode R and Bajaj A, 2010 “Formulation and Development Of Once A Daily Sustained Release Matrix Tablet For Pramipexole” IJPI’s Journal of Pharmaceutics and Cosmetology 1.
17. Radhikaa PR, Pala TK, Sivakumar T, “Formulation and Evaluation of Sustained Release Matrix Tablets of Glipizide” Iranian Journal of Pharmaceutical Sciences” 2009; 5(4) 205-214.