Volume : 09, Issue : 06, June – 2022
Title:
12.FORMULATION, DEVELOPMENT AND EVALUATION OF OCULAR IN SITU GEL OF NSAIDS DRUG NEPAFENAC
Authors :
Kundan Singh, Dr. Janki Prasad Rai, Dr.Akhlesh Kumar Singhai,
Ms. Sushma Somkuvar, Dr. Manju Prajapati
Abstract :
In situ gels are systems which are applied as solutions or suspensions and are capable of undergoing rapid sol-to-gel transformation triggered by external stimulus such as temperature, pH etc. on instillation. The aim of the present study was to formulate and evaluate pH responsive in-situ gel for ophthalmic delivery. Ophthalmic nepafenac is used to treat eye pain, redness, and swelling in patients who are recovering from cataract surgery (procedure to treat clouding of the lens in the eye). Nepafenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the production of certain natural substances that cause pain and swelling. Ophthalmic in situ gelling system of Nepafenac was successfully formulated using polymeric combination of gelling agents Pluronic F127, Carbopol 934 as, temperature sensitive and pH-sensitive respectively along with HPMC 15cps as viscosity enhancing agent. All the formulations except F7, F8 and F9 showed instantaneous gelation when contacted with simulated tear fluid (STF), formulation F6 showed best gelation property amongst all other. Formulation F6 showed sustained drug release for a period of 6 hour. The In vitro drug release data of the optimized formulation was subjected to goodness of fit test by linear regression analysis according to zero order, first order Higuchi and Korsmeyerpeppas release kinetic equation in order to determine the mechanism of drug release.
Key words:Nepafenac, nonsteroidal anti-inflammatory drugs, Ophthalmic, In situ gel
Cite This Article:
Please cite this article in pressKundan Singhet al,Formulation, Development And Evaluation Of Ocular In Situ Gel Of Nsaids Drug Nepafenac.,Indo Am. J. P. Sci, 2022; 09(6).,
Number of Downloads : 10
References:
1. Patel Nisha, Shinde Gajanan, Rajesh KS. Ophthalmic In situ gel, A genesis journal Pharmagene, 2(4), 2014, 29-33.
2. F. Suisha, N. Kawasaki, S. Miyazaki, M. Shirakawa, K. Yamatoya, M. Sasaki, D. Attwood, Xyloglucan gels as sustained release vehicles for the intraperitoneal administration of mitomycin C. Int. J. Pharm., 172, 1998, 27–32
3. Miyazaki S, Endo K, Kawasaki N, Kubo W, Watanabe H, Attwood D. Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. Drug Dev Ind. Pharm., 29(2), 2003, 113-9.
4. Nerkar Tushar, GujarathiNayan A, Rane Bhushan R, Bakliwal Sunil R, Pawar S.P. In situ gel: Novel Approch in sustained and controlled drug delivery system. International Journal of Pharmaceutical sciences, 4(4), 2013, 1-18.
5. Saraswat R., Bhan C. S., Gaur A. A Review on Polymers Used In In-Situ Gel Drug Delivery Systems, 1(2), May-Jun 2011.
6. Varshosaz J, Tabbakhian M, Salmani Z. Designing of a Thermosensitive Chitosan/Poloxamer insitu Gel for Ocular Delivery of Ciprofloxacin. The Open Drug Delivery Journal. 2008; 2(1):61-70.
7. Saxena P, Kushwaha SK. Temperature sensitive ophthalmic hydrogels of levofloxacin hemihydrate with enhanced solubility and prolonged retention time. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(3):77-883.
8. Viram P, Lumbhani AN. Development and evaluation of ion-dependent insitu nasal gelling systems of metoclopramide hydrochloride as an antimigraine model drug. International Journal of Latest Research in Science and Technology. 2012; 1(2):80-9.
9. Vodithala S, Khatry S, Shastri N, Sadanandam M. Development and evaluation of Thermoreversible Ocular Gels of ketorolac tromethamine. International Journal of Biopharmaceutics. 2010; 1(1):39-45.
10. Shankar SJ, Kalikonda A. pH induced insitu gel formulation of Lomefloxacin HCl. Universal Journal of Pharmacy. 2014; 3(1): 38-43.
11. Mahesh NS, Manjula BP. Study of an Alginate /HPMC based in situ gelling opthalmic delivery system for levofloxacin hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4(3):655-8.
12. Costa P, Lobo JMS. Modelling and comparison of dissolution profiles. European Journal of Pharmaceutical Science. 2001; 13:123-33.
13. Gratieri T, Martins G, Freitas O De, Melani E. Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan insitu forming gel. European Journal of Pharmaceutics and Biopharmaceutics. 2011; 79:320-27.