Volume : 09, Issue : 06, June – 2022

Title:

20.GASTROESOPHAGEAL REFLUX DISEASE PREVALENCE AND IMPACT ON THE QUALITY OF LIFE AMONG PRIMARY HEALTHCARE CENTERS SAUDI VISITORS IN TAIF CITY, KSA IN 2022

Authors :

Dr. Naseem Saleem Altowairqi, Dr. Majed Khalaf Alharthi

Abstract :

Aim: The study aimed to determine the magnitude of the problem of Gastroesophageal reflux disease (GERD) and its impact on quality of life among patients attending primary health care centers, Ministry of Health, Taif, KSA. Methods: The study population constituted adult patients (18-62 years) attending the 19 primary health care centers, belonging to Ministry of Health in Taif, KSA. We used the GERD Questionnaire (GerdQ) to assess the burden and prevalence of GERD, and the WHOQOL-BREF tool to assess the life quality of participants. We analysed the data using the Statistical Package for Social Sciences (SPSS) version 26. Results: The study included 325 participants, whose age ranged from 18 to 62 years, with a mean of 37±12.6. Females constituted 54.2% of the sample, and nearly half of the participants (50.2%) had university education or more. The GerdQ average score among respondents was 8±5. The participants that scored 8 and higher were 29.8%. On the other hand, the overall quality of life score was 12.7±6.3, where the physical health and social relationships domains score were the highest (59.5±32.9, and 58.8±32.3, respectively). GerdQ score was significantly associated with educational level (p=0.009), presence or absence of chronic diseases (p=0.009), and BMI (p=0.000). There was a significant association between all the QoL domains with age (p=0.000), educational level (p=0.000), marital status (p=0.000), smoking status (p=0.000), presence or absence of chronic diseases (p=0.000), BMI (p<0.05), and average monthly family income (p<0.05). Conclusion: The GerdQ and quality of life scores had a significant negative correlation. University graduates, those with chronic conditions, and those with overweight and normal BMI all had higher GerdQ scores (more GERD symptoms). We recommend more emphases to screen, assess, and manage GERD among the general public as the prevalence of the condition is relatively high, and it has a significant negative effect on the life quality.

Cite This Article:

Please cite this article in press Varun Kumar et al, Formulation and Evaluation of Enteric Coated Tablets Pantoprazole sodium by Direct Compression Method., Indo Am. J. P. Sci, 2022; 09(6).,

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References:

1. Bredenoord AJ, Pandolfino JE, Smout AJ. Gastro-oesophageal reflux disease. Lancet. 2013;381:1933–42.
2. El-Serag HB. Time trends of gastroesophageal reflux disease: A systematic review. Clin Gastroenterol Hepatol. 2007;5:17–26.
3. Fujiwara Y, Higuchi K, Watanabe Y, Shiba M, Watanabe T, Tominaga K, et al. Prevalence of gastroesophageal reflux disease and gastroesophageal reflux disease symptoms in Japan. J Gastroenterol Hepatol. 2005;20:26–9.
4. Shaheen NJ, Hansen RA, Morgan DR, Gangarosa LM, Ringel Y, Thiny MT, et al. The burden of gastrointestinal and liver diseases. 2006. Am J Gastroenterol. 2006;101:2128–38.
5. Wong WM, Lai KC, Lam KF, Hui WM, Hu WH, Lam CL, et al. Prevalence, clinical spectrum and health care utilization of gastrooesophageal reflux disease in a Chinese population: A population-based study. Aliment Pharmacol Ther. 2003;18:595–604.
6. Vossoughinia H, Salari M, Mokhtari Amirmajdi E, Saadatnia H, Abedini S, et al. An epidemiological study of gastroesophageal reflux disease and related risk factors in urban population of Mashhad, Iran, Iran Red Crescent Med J. 2014 ; 16(12):e15832. doi: 10.5812/ircmj.15832
7. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.
8. McDougall NI, Johnston BT, Kee F, Collins JS, McFarland RJ, Love AH. Natural history of reflux oesophagitis: A 10 year follow up of its effect on patient symptomatology and quality of life. Gut. 1996;38:481–6
9. Wahlqvist P, Karlsson M, Johnson D, Carlsson J, Bolge SC, Wallander MA. Relationship between symptom load of gastro-oesophageal reflux disease and health-related quality of life, work productivity, resource utilization and concomitant diseases: Survey of a US cohort. Aliment Pharmacol Ther. 2008;27:960–70.
10. Jansson C, Wiberg M, Alexanderson K. Sickness absence due to gastroesophageal reflux diagnoses: A nationwide Swedish population based study. Scand J Gastroenterol. 2013;48:17–26.
11. Mostaghni A, Mehrabani D, Khademolhosseini F, Masoumi SJ, Moradi F, Zare N, et al. Prevalence and risk factors of gastroesophageal reflux disease in Qashqai migrating nomads, southern Iran. World J Gastroenterol. 2009;15:961–5.
12. Nasseri-Moghaddam S, Mofid A, Ghotbi MH, Razjouyan H, Nouraie M, Ramard AR, et al. Epidemiological study of gastrooesophageal reflux disease: Reflux in spouse as a risk factor. Aliment Pharmacol Ther. 2008;28:144–53.
13. Nouraie M, Radmard AR, Zaer-Rezaii H, Razjouyan H, Nasseri-Moghaddam S, Malekzadeh R. Hygiene could affect GERD prevalence
1. independently: A population-based study in Tehran. Am J Gastroenterol. 2007;102:1353-60.
14. Nouraie M, Razjouyan H, Assady M, Malekzadeh R, Nasseri-Moghaddam S. Epidemiology of gastroesophageal reflux symptoms in
2. Tehran, Iran: A population-based telephone survey. Arch Iran Med. 2007;10:289-94.
15. Solhpour A, Pourhoseingholi MA, Soltani F, Zarghi A, Habibi M, Ghafarnejad F, et al. Gastro-esophageal reflux symptoms and body mass index: No relation among the Iranian population. Indian J Gastroenterol. 2008; 27:153–5.
16. Kitapcioglu G, Mandiracioglu A, Caymaz Bor C, Bor S. Overlap of symptoms of dyspepsia and gastroesophageal reflux in the community. Turk J Gastroenterol. 2007;18:14-9.
17. Sperber AD, Halpern Z, Shvartzman P, Friger M, Freud T, Neville A, et al. Prevalence of GERD symptoms in a representative Israeli adult population. J Clin Gastroenterol. 2007;41:457–61.
18. Atta MM, Sayed MH, Zayed MA, Alsulami SA, Al-Maghrabi AT, Kelantan AY. Gastro-oesophageal reflux disease symptoms and associated risk factors among medical students, Saudi Arabia. Int J Gen Med. 2019 Aug 19;12:293-298. doi: 10.2147/IJGM.S206995
19. Altwigry AM, Almutairi MS, Ahmed M. Gastroesophageal reflux disease prevalence among school teachers of Saudi Arabia and its impact on their daily life activities. Int J Health Sci (Qassim). 2017 Apr-Jun;11(2):59-64.
20. Binhussein M, Alamoudi A, Bajawi A, Alghafis M, Baz M, Bakhsh R. et al. Prevalence of gastro-oesophageal reflux in western region of Saudi Arabia. Saudi J Gastroenterol. 2016;22(7):pS13. Retrieved from: http://www.saudijgastro.com/article.asp?issn=13193767;year=2016;volume=22;issue=7;spage=1;epage=24;aulast=
21. Almadi MA, Almousa MA, Althwainy AF, Altamimi AM, Alamoudi HO, Alshamrani HS, Alharbi OR. et al. Prevalence of symptoms of gastroesopahgeal reflux in a cohort of Saudi Arabians: a study of 1265 subjects. Saudi J Gastroenterol. 2014;20(4):248–254. doi:10.4103/1319-3767.136982.
22. Alsuwat OB, Alzahrani AA, Alzhrani MA, Alkhathami AM, Mahfouz MEM. Prevalence of Gastroesophageal Reflux Disease in Saudi Arabia. J Clin Med Res. 2018;10(3):221–225. doi:10.14740/jocmr3292w
23. Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2005; 54(5): 710 -7
24. Saberi-Firoozi M, Khademolhosseini F, Yousefi M, Mehrabani D, Zare N, Heydari ST. Risk factors of gastroesophageal reflux disease in Shiraz, southern Iran. World J Gastroenterol. 2007; 13(41): 5486 -91
25. Locke GR, 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ, 3rd.. Risk factors associated with symptoms of gastroesophageal reflux. Am J Med. 1999; 106(6): 642 -9
26. Dent J, Brun J, Fendrick A, Fennerty MB, Janssens J, Kahrilas P, et al. An evidence-based appraisal of reflux disease management the Genval workshop report. Gut. 1998;44(Suppl 2):S1-16.
27. Wiklund I. Review of the quality of life and burden of illness in gastroesophageal reflux disease. Dig Dis. 2004; 22:108–14.
28. Chen MJ, Wu MS, Lin JT, Chang KY, Chiu HM, Liao WC, et al. Gastroesophageal reflux disease and sleep quality in a Chinese population. J Formos Med Assoc. 2009; 108:53–60
29. Lee S-W, Chang C-M, Chang C-S, Kao A-W, Chou M-C. Comparison of presentation and impact on quality of life of gastroesophageal reflux disease between young and old adults in a Chinese population. World J Gastroenterol 2011 November; 17(41): 4614-461
30. Chen M, Xiong L, Chen H, Xu A, He L, Hu P. Prevalence, risk factors and impact of gastroesophageal reflux disease symptoms: a population-based study in South China. Scand J Gastroenterol. 2005 Jul;40(7):759-67
31. Cardoso AL, Figueiredo AGA, Sales LGD, Neta AMS, Barreto IDC, Trindade LMDF. Gastroesophageal reflux disease: prevalence and quality of life of health science undergraduate students. Acta Gastroenterol Latinoam 2018;48(3):197-205
32. Wang R, Zou D, Ma X, Zhao Y, Yan X, Yan H, el al. Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological study. Health Qual Life Outcomes. 2010 Nov 10;8:128. doi: 10.1186/1477-7525-8-128.
33. Spantideas N, Drosou E, Bougea A, Assimakopoulo D. Gastroesophageal reflux disease symptoms in the Greek general population: prevalence and risk factors. Clinical and Experimental Gastroenterology 2016:9 143–149. DOI https://doi.org/10.2147/ CEG. S103485
34. Macrotrends. Taif, Saudi Arabia population 1950-2019. Available at: https://www.macrotrends.net/cities/22434/taif/pop
35. Bartlett J. Kotrlik JW, Higgins CC. Organizational Research: Determining Appropriate Sample Size in Survey Research, 2001. Retrieved January 15, 2018 from: http://citeseerx.ist.psu.edu/viewdoc/download?doi =10.1.1. 486.8295&rep=rep1&type=pdf.
36. Jones R, Junghard O, Dent J, Vakil N, Halling K, Wernersson B, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care. Aliment Pharmacol Ther. 2009;30:1030–8
37. Bonomi AE, Patrick DL, Bushnell DM, Martin M. Validation of the United States’ version of the World Health Organization Quality of Life (WHOQOL) instrument. J Clin Epidemiol [Internet]. 2000 Jan;53(1):1–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10693897
38. Skevington SM, Lotfy M, O’Connell KA. The World Health Organization’s WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL Group. Qual Life Res [Internet]. 2004 Mar;13(2):299–310. Available from: http://link.springer.com/10.1023/B:QURE. 0000018486. 91360.00
39. Al Sayah F, Ishaque S, Lau D, Johnson JA. Health related quality of life measures in Arabic speaking populations: A systematic review on cross-cultural adaptation and measurement properties. Qual Life Res [Internet]. 2013 Feb 18;22(1):213–29. Available from: http://link.springer.com/10. 1007/ s11136-012-0129-3
40. Ohaeri J, Awadalla A. The reliability and validity of the short version of the WHO quality of life instrument in an Arab general population. Ann Saudi Med [Internet]. 2009;29(2):98. Available from: https://www.ncbi. nlm. nih. gov/pmc/articles/PMC2813624/
41. Zimet GD, Dahlem NW, Zimet SG, Farley GK. The Multidimensional Scale of Perceived Social Support. J Pers Assess 1988 Mar;52(1):30–41.
42. WHO. Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychol Med. 1998;28(3):551–8.
43. Orlando RC. Reflux esophagitis. In: Yamada T, Alpers DH, Owyang C, Powell DW, Laine L (eds.). Textbook of gastroenterology. Lippincott Williams Wilkins, Philadelphia 1999; 1235–1263.
44. Reguła J. Epidemiologia choroby refluksowej w Polsce. Materiały IX Warszawskich Spotkań Gastroenterologicznych. Wydawnictwo Goldprint, Warszawa. 2003;22-25.
45. Revicki DA, Zodet MW, Joshua-Gotlib S, Levine D, Crawley JA. Health-related quality of life improves with treatment-related GERD symptom resolution after adjusting for baseline severity. Health Qual Life Outcomes. 2003;1:73.
46. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900-1920; quiz 1943.
47. Dent J, Brun J, Fendrick AM, Fennerty MB, Janssens J, Kahrilas PJ, Lauritsen K, Reynolds JC, Shaw M, Talley NJ. An evidence-based appraisal of reflux disease management—the Genval Workshop Report. Gut. 1998 Apr 1;44(suppl 2):S1-6.
48. Jansson C, Nordenstedt H, WALLANDER MA, Johansson S, Johnsen R, Hveem K, Lagergren J. Severe gastro‐oesophageal reflux symptoms in relation to anxiety, depression and coping in a population‐based study. Alimentary pharmacology & therapeutics. 2007 Sep;26(5):683-91.
49. Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms. Jama. 2003 Jul 2;290(1):66-72.
50. Nojkov B, Rubenstein JH, Adlis SA, Shaw MJ, Saad R, Rai J, Weinman B, Chey WD. The influence of co‐morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro‐oesophageal reflux disease. Alimentary pharmacology & therapeutics. 2008 Mar;27(6):473-82.