Volume : 09, Issue : 06, June – 2022
23.FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NATEGLINIDE BY USING NATURAL POLYMERS
M.Sai Lakshmi, S. Gopi Krishna, R.Roopa Rani, K.Divya, K.Dhana Sri, M.Gopika
For treating diabetes, it has been considered important that both a post prandial blood glucose level and a fasting blood glucose level are decreased to make them to normal levels. Nateglinide [N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine] is a novel mealtime glucose regulator approved for the treatment of type II diabetes mellitus. Once a day sustained release matrix tablets of nateglinide was prepared by using natural polymers k-carrageenan,lambda carrageenan and locust bean gum. Natural polymers were selected due to their easy availability and cheaper in coast and we can get standard uniformity and combinations of two different gums carrageenan and locust been gum were formulated in different ratios to exploit the rheological synergism between two gums in order to achive once a day matrix tablets of nateglinide further formulations were prepared from the formulations exhibited maximum retardation the controlled or sustained release formulations of nateglinide would be more useful than the nateglinide immediate release tablets from the new point of side effects improvement of compliance to patients and to enable to control of both post prandial blood glucose level and fasting blood glucose level for moderate and sever diabates patients. Hence an attempt was made to develop a sustained release oral dosage form of nateglinide instead of immediate release tablet.
Keywords: Nateglinide, Matrix Tablets, Sustained Release, Natural Polymers.
Cite This Article:
Please cite this article in press M. Sai Lakshmi et al, Formulation Development And Invitro Evaluation Of Sustained Release Matrix Tablets Of Nateglinide By Using Natural Polymers., Indo Am. J. P. Sci, 2022; 09(6).,
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1. 1.Gupta PK and Robinson JR. Oral controlled release delivery. Treatise on controlled drug delivery. 1992;93(2):545-555.
2. Jantzen GM and Robinson JR. Sustained and Controlled- Release Drug Delivery systems. Modern Pharmaceutics. 1995; 121(4): 501-502.
3. Altaf AS, Friend DR, MASRx and COSRx Sustained-Release Technology in Rathbone MJ, Hadgraft J, and Robert MS. Modified Release Drug Delivery Technology, Marcel Dekker Inc., New York, 2003; 126: 996.
4. 4.Gwen MJ and Joseph RR, In Banker GS and Rhodes CT, Eds. Modern Pharmaceutics, Marcel Dekker Inc. New York, 1996; 72(3): 575.
5. Salsa T, Veiga F and Pina ME. Oral controlled release dosage form. I. cellulose ether polymers in hydrophilic matrices. Drug Develop. Ind. Pharm. 1997; 23: 929-938.
6. Wani MS et al. Controlled Release system-A Review. Pharmaceutical Reviews. 2008; 6(1): 41-46.
7. Altaf AS, Friend DR, MASRx and COSRx Sustained-Release Technology in Rathbone MJ, Hadgraft J, Robert MS, Modified Release Drug Delivery Technology, Marcell Dekker Inc., New York, 2003. JPSBR: Volume 1, Issue 3: Nov Dec 2011 (143-151) Patel H. 151
8. Vidyadhara S, Rao PR, Prasad JA. Formulation And Evaluation Of Propranolol Hydrochloride Oral Controlled Release Matrix Tablets. Indian J.Pharm Sci, 2004; 66: 188-192.
9. Reddy KR, Mutalik S, Reddy S. Once-daily sustained release matrix tablets of Nicorandil: Formulation and in vitro evaluation,AAPS Pharm. Sci. Tech.,2003; 4: 1-9.
10. Mohammed AD, James LF, Michael HR, John EH, Rajabi-Siahboomi AR. Release of Propranolol hydrochloride from matrix tablets containing sodium carboxy methylcellulose and Hydroxy propyl methyl cellulose. Phar. Dev. Tech.,1999; 4: 313-324.
11. Lee BJ, Ryu SG, Cui JH. Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin. Drug Dev. Ind.Pharm.,1999; 25: 493-501.
12. Chowdary KPR, Rao YS. Design and in vitro and in vivo evaluation of mucoadesive microcapsules of glipizide for oral controlled release. AAPS Pharm Sci Tech 2003; 4: 1-6.
13. Cooper J, Gunn C. Powder flow and compaction. In: Carter SJ, (editor). Tutorial pharmacy. New Delhi: CBS Publishers and distributors, 1986; pp. 211-33.
14. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Philadelphia: Lea & Febieger, 1970; pp. 68-9.
15. The Pharmacopoeia of India. New Delhi: Controller of Publication, 1996; pp.736.
16. Rawlins EA. Bentley’s text book of pharmaceutics. London: Cassell and Colloer Macmillian, 1977.  Hadjioannou TP, Christain GD, Koupparis MA. Quantitative calculations in pharmaceutical practice and research. New York: VCH Publishers Inc., 1993; pp. 345-8.
17. Bourne DW. Pharmacokinetics. In: Banker GS, Rhoides CT, (editors). Modern pharmaceutics. 4th ed. New York: Marcel Dekker Inc. 2002; 67-92.