Volume : 09, Issue : 06, June – 2022

Title:

24.FORMULATION DEVELOPMENT OF FAMOTIDINE GASTRORETENTIVE TABLETS BY MELT GRANULATION TECHNIQUE
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Authors :

H. Padmalatha

Abstract :

The aim of the present study is to formulate and evaluate gastro retentive tablet of famotidine for the treatment of peptic ulcer, thus the action would be specifically in the stomach. Preformulation studies which include Organoleptic properties, Bulk and Tapped densities, Carr’s index, Hausner’s ratio, Melting point, PH , Solubility, were carried out are as per IP specifications. Drug-excipient compatibility studies were performed which shows that there is no interaction between drug and polymers. Evaluation studies have been performed for tablets include friability, hardness, weight variation, content uniformity, buoyancy studies are as per IP specifications. Drug release studies have been performed by using 0.1N Hcl for 12 hrs. These studies have shown that the formulation F4 gave better drug release upto 12 hrs. which is formulated with HPMC K100 M. Drugs that have poor bio-availability because of their limited absorption to the upper gastrointestinal tract can be delivered efficiently into FDDS. Thereby maximizing their absorption and improving their absolute bioavailability. The floating concept can also be utilized in the development to treating various diseases. Buoyant delivery system considered as a beneficial strategy for the treatment of gastric and duodenal cancers.
KEYWORDS: Famotidine, Gastroprotective Tablets, Melt Granulation Technique, Kinetic Study

Cite This Article:

Please cite this article in press H. Padmalatha, Formulation Development Of Famotidine Gastroretentive Tablets By Melt Granulation Technique.,Indo Am. J. P. Sci, 2022; 09(6).,

Number of Downloads : 10

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