Volume : 09, Issue : 06, June – 2022



Authors :

Dr. Rukhsar Javeed, Dr. Omaima Ramzan, Dr. Asad Javeed, Owais Muhammad Omar

Abstract :

Human papillomavirus is an oncogenic DNA virus that has been found in 97.8 percent of invasive tumor cases. This is the most common virus implicated in sexually transmitted diseases globally in addition a major public health problem for deterrence strategies. In women, cervical cancer is the second leading source of malignant neoplasia also mortality. The present research however was conducted to recognize HPV infection danger variables in normal and diseased cervixes of females attending tertiary care hospitals. The Hybrid Capture 2 test, which assessed HPV high hazard types, was used to identify HPV DNA in the research sample. This cross-sectional research comprised 68 women ranging in age from 27 to 74 years. Thirteen (18.2%) of the patients tested positive for HPV DNA. Initial fleshly interaction, lower level of education, early marriage, multi-equality, over-all period of sexual intercourse in years, long-term usage of the oral contraceptive pill, and poor socioeconomic situation were found as risk factors for HPV infection. Enhanced HPV disease knowledge and comprehension could prevent infections and enhance control in sexually active women. HPV detection in the primary infection is critical. Given the cost of the HPV test, its implementation in routine cervical mass screening might remain impossible in impoverished nations such as Pakistan. Nonetheless, when paired with cytology, it has been found to be a beneficial tool for diagnosing elevated contagion in seemingly normal tissues, and it could assist to lower the danger of developing cervical cancer. The research findings will eventually help to avoid cervical cancer in Pakistani females.
Keywords: Human papillomavirus, oncogenic, invasive cancer, Gynecology, Oncology.

Cite This Article:

Please cite this article in press Rukhsar Javeed et al, Cervical Cancer Risk Connected With HPV Infection In Gynecologic Outdoor Patients Visiting Mayo Hospital Lahore., Indo Am. J. P. Sci, 2022; 09(6).,

Number of Downloads : 10


1. Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 2019; 189: 12- 19.
2. Moscicki AB, Schiffman M, Burchell A, et al. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine. 2021; 30(Suppl 5): F24- F33.
3. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2020; 370: 890- 907.
4. Hinten F, Hilbrands LB, Meeuwis KAP, et al. Reactivation of latent HPV infections after renal transplantation. Am J Transplant. 2019; 17: 1563- 1573.
5. Liu SH, Cummings DA, Zenilman JM, et al. Characterizing the temporal dynamics of human papillomavirus DNA detectability using short-interval sampling. Cancer Epidemiol Biomark Prev. 2020; 23: 200- 208.
6. Paul P, Hammer A, Rositch AF, et al. Rates of new human papillomavirus detection and loss of detection in middle-aged women by recent and past sexual behavior. J Infect Dis. 2021; 223: 1423- 1432.
7. Strickler HD, Burk RD, Fazzari M, et al. Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst. 2020; 97: 577- 586.
8. Heard I, Tassie JM, Schmitz V, Mandelbrot L, Kazatchkine MD, Orth G. Increased risk of cervical disease among human immunodeficiency virus-infected women with severe immunosuppression and high human papillomavirus load(1). Obstet Gynecol. 2020; 96: 403- 409.
9. Maglennon GA, McIntosh P, Doorbar J. Persistence of viral DNA in the epithelial basal layer suggests a model for papillomavirus latency following immune regression. Virology. 2021; 414: 153- 163.
10. Maglennon GA, McIntosh PB, Doorbar J. Immunosuppression facilitates the reactivation of latent papillomavirus infections. J Virol. 2020; 88: 710- 716.