Volume : 09, Issue : 06, June – 2022
Title:
38.FORMULATION AND EVALUATION OF FLOATING TABLET OF TELMISARTAN
Authors :
Jeetendra Harijan, Shailendra Modi, Sanjay Jain, Dr. Vijay Nigam
Abstract :
The aim of present investigation was to formulate and evaluate floating tablet of telmisartan. Telmisartan is a non-peptide angiotensin II receptor antagonist. Telmisartan blocks the vasoconstriction and aldosterone secreting effects of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, leading to a reduction in arterial blood pressure. The poor bioavailability of Telmisartan (40-58%) was the criteria which caused the selection of drug, which could be increased by prolonging the gastric retention time so that it remain in the acid environment until all the drug is released. U.V. Scanning of Telmisartan was performed and the λmax at 295 nm was found to be the most appropriate for the determination of concentration of unknown samples. Standard curve of telmisartan was prepared at in 0.1N HCl and the correlation was found to be 0.992 respectively. The tablets of various formulations of telmisartan were prepared and the tablet hardness was found to be in range of 3.01 to 8.24 kg/cm3. The average weight of the prepared tablets of various formulations was found to be with in the Pharmacopoeial limit i.e. ± 7.5% The average percentage (%) drug content was also found with in the Pharmacopoeial limit and shows the effectiveness of the mixing procedure. Formulation F4, F8, F12 having 12 mg MKG content were showing 72.37±2.78, 69.23±2.72, 68.87±3.89 cumulative drug release in 12 hrs. in case of formulations F1, F1, F5, F9, having katira gum content 9 mg were showing 83.52±2.22, 81.56±2.47, 82.71±2.95. From the results obtained, it was concluded that the formulation F7 is the best formulations as the extent of drug release was found to be around 75.44%. This batch also showed immediate floatation and floatation duration of more than 8hr. The drug release model of this formulations comply with Peppas model kinetics.
KEYWORDS: Telmisartan, Gond Katira., Avicel-101, 0.1 N HCl , Methanol, Magnesium sterate, Talc
Cite This Article:
Please cite this article in press Jeetendra Harijan et al, Formulation And Evaluation Of Floating Tablet Of Telmisartan., Indo Am. J. P. Sci, 2022; 09(6).,
Number of Downloads : 10
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