Volume : 09, Issue : 06, June – 2022
Title:
54.EFFECT OF CASTING SOLVENT ON PERMEABILITY OF FLURBIPROFEN THROUGH EUDRAGIT RLPO FILMS
Authors :
Girija * J. N. Suresh and Syed. Gouse Firoz
Abstract :
In the present work, Eudragit RLPO films were prepared and evaluated as rate controlling membrane for transdermal drug delivery systems. Acetone, chloroform, dichloromethane and ethyl acetate were used as solvents in the preparation of films. Dibutyl phthalate at a concentration of 15% w/w of the polymer was used as a plasticizer in the preparation films. The solvent evaporation technique was found to be giving thin uniform films. The dry films were evaluated for Physical appearance, Thickness uniformity, Folding endurance, Water Vapour Transmission, Drug diffusion and Permeability Coefficient. Both Water vapour transmission and Drug diffusion rate followed zero order kinetics. The mechanism of drug release was governed by peppas model. The diffusion exponent of release profiles (slope) has a value of n>1, which indicates non analmous transport diffusion. The results obtained in the present study thus indicated that the solvents used in the preparation of films have been shown significant influence on the water vapour transmission, drug diffusion and permeability of the films. Eudragit RLPO films employed with ethyl acetate as casting solvent shown high Permeability when compared to other films for both drugs .
Key Words: Solvents, Water Vapour Transmission, Drug diffusion and Permeability Coefficient.
Cite This Article:
Please cite this article in press Girija et al, Effect Of Casting Solvent On Permeability Of Flurbiprofen Through Eudragit RLPO Films., Indo Am. J. P. Sci, 2022; 09(6).,
Number of Downloads : 10
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