Volume : 09, Issue : 06, June – 2022

Title:

62.STABILITY INDICATING NOVEL METHOD FOR THE DETERMINATION OF PALIPERIDONE IN BULK AND DOSAGE FORM BY USING RP-HPLC
‬

Authors :

Syed Hafeez Ahmed, Anil Kumar Middha

Abstract :

A new precise, accurate, rapid method has been developed for the estimation of PALIPERIDONE in pharmaceutical dosage form by HPLC. The optimum wavelength for the determination of PALIPERIDONE was selected at 284 nm. Various trials were performed with different mobile phases in different ratios, but Ammonium acetate buffer pH-5.0 : Acetonitrile (60:40) was selected as good peak symmetry and resolution between the peaks was observed. The retention times for the drug were considerably less compared to the retention time obtained for the drugs in the other mobile phase. The calibration curve was obtained by plotting peak area versus the concentration over the range of 60-140 µg/mL for PALIPERIDONE. From linearity the correlation coefficient R2 value was found to be 0.999 for PALIPERIDONE. The proposed HPLC method was also validated for system suitability, system precision and method precision. The %RSD in the peak area of drug was found to be less than 2%. The number of theoretical plates was found to be more than 2000, which indicates efficient performance of the column. The percentage of recovery of PALIPERIDONE was found to be 99.6% respectively shows that the proposed method is highly accurate.
Keywords: PALIPERIDONE, RP-HPLC, Method Development & Validation.

Cite This Article:

Number of Downloads : 10

References: