Volume : 09, Issue : 03, March – 2022

Title:

11.EPIDEMIOLOGY OF OVARIAN CANCER: AN UPDATED SYSTEMATIC REVIEW (2019-2021)

Authors :

Amani althaya albanaqi and Khalida Hamad Alotaibi

Abstract :

Background: Ovarian cancer (OC) is expected to cause 239,000 new cases and 152,000 deaths globally each year. Almost all benign and malignant ovarian tumors are caused by one of three types of cells: epithelial cells, stromal cells, or germ cells. The prevalence of OC varies significantly across the countries. Several risk factors have been associated with OC incidence. Among these risk factors are Family history, menarche and menopause age, pregnancy, lactation, obesity, and contraceptives use.
Aim: To assess the epidemiology of ovarian cancer in females, including risk factors, diagnosis, survival, racial differences and other characteristics.
Methods: Studies related to our subject were explored using PubMed and Google scholar databases during 2019 to 2021. The included searching keywords were “Ovarian cancer (OC), Epidemiology, Risk factors, OC diagnosis, OC survival, OC racial and ethnic characteristics” and were used in various combinations. The inclusion criteria were original studies reported ovarian cancer epidemiology conducted on females and full text- articles.
Results: A total of 125 articles were obtained, only eleven articles were eligible for the inclusion criteria. The involved studies were conducted on a total number of 62459 participants. Out of 11 studies included, 3 studies were published in 2019, 7 studies in 2020 and 1 study in 2021. Four studies were cross-sectional, six cohort studies and one study based on data from SEER program.
Conclusion: The average age of the OC patients in our sample was 52.5 years. Granulosa tumours and high-grade serous carcinoma were the most common histological characteristics of ovarian cancer. Non-Hispanic black women were shown to have a greater overall mortality risk than non-Hispanic white women. More research is needed to investigate the involvement of unknown risk factors in the development of ovarian cancer.
Keywords: Ovarian cancer (OC), Epidemiology, Risk factors, OC diagnosis, OC survival and OC racial and ethnic characteristics.

Cite This Article:

Please cite this article in press Amani althaya albanaqi et al, Epidemiology Of Ovarian Cancer: An Updated Systematic Review (2019-2021)., Indo Am. J. P. Sci, 2022; 09(3),.

Number of Downloads : 10

References:

1. Younes N, Zayed H. Genetic epidemiology of ovarian cancer in the 22 Arab countries: a systematic review. Gene. 2019 Feb 5;684:154-64.
2. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25676887 patients from 279 population-based registries in 67 countries (CONCORD-2) Lancet. 2015;385:977–1010.
3. Elmahi HB. The Frequency of Survivin expression among Sudanese Women with Ovarian Cancer (Doctoral dissertation, Asma El-ameer Mohammed Zeen).
4. Barnes BM, Nelson L, Tighe A, Burghel GJ, Lin I, Desai S, McGrail JC, Morgan RD, Taylor SS. Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes. Genome medicine. 2021 Dec;13(1):1-9.
5. Wei KR, Li YM, Zheng RS, Zhang SW, Liang ZH, Cen HS, et al. Ovary cancer incidence and mortality in China, 2011. Chin J Cancer Res. 2015;27:38–43.
6. Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL. Ovarian cancer statistics, 2018. CA: a cancer journal for clinicians. 2018 Jul;68(4):284-96.
7. Momenimovahed Z, Tiznobaik A, Taheri S, Salehiniya H. Ovarian cancer in the world: epidemiology and risk factors. International journal of women’s health. 2019;11:287.
8. Reid BM, Permuth JB, Sellers TA. Epidemiology of ovarian cancer: a review. Cancer biology & medicine. 2017 Feb;14(1):9.
9. Moorman PG, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Crankshaw S. Reproductive factors and ovarian cancer risk in African-American women. Annals of epidemiology. 2016 Sep 1;26(9):654-62.
10. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS medicine. 2009;6(7):e1000100.
11. Kurian AW, Ward KC, Howlader N, Deapen D, Hamilton AS, Mariotto A, Miller D, Penberthy LS, Katz SJ. Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients. Journal of Clinical Oncology. 2019 May 20;37(15):1305.
12. Prakosa T, Mudigdo A, Purwanto B, Wasita B, Cilmiaty R, Widianingsih V. A cross-sectional study: The correlation of pro-angiogenic factors expression level and epithelial ovarian cancer staging. Bali Medical Journal. 2020;9(1):125-8.
13. Van Calster B, Valentin L, Froyman W, Landolfo C, Ceusters J, Testa AC, Wynants L, Sladkevicius P, Van Holsbeke C, Domali E, Fruscio R. Validation of models to diagnose ovarian cancer in patients managed surgically or conservatively: multicentre cohort study. bmj. 2020 Jul 30;370.
14. Funston G, Hamilton W, Abel G, Crosbie EJ, Rous B, Walter FM. The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study. PLoS medicine. 2020 Oct 28;17(10):e1003295.
15. Bennetsen AK, Baandrup L, Aalborg GL, Kjaer SK. Non-epithelial ovarian cancer in Denmark–Incidence and survival over nearly 40 years. Gynecologic oncology. 2020 Jun 1;157(3):693-9.
16. Umakanthan S, Chattu VK, Kalloo S. Global epidemiology, risk factors, and histological types of ovarian cancers in Trinidad. Journal of family medicine and primary care. 2019 Mar;8(3):1058.
17. Moterani VC, Tiezzi DG, de Andrade JM, Candido dos Reis FJ. Analysis of the relationship between hospital characteristics and survival in ovarian cancer: A historical cohort. Journal of Surgical Oncology. 2020 Dec;122(8):1802-7.
18. Sindiani A, Obeidat B, Hamadeh L, Alghazo S, Al-Mohtaseb A, Alshdaifat E. A descriptive study of the clinico-pathological and surgical characteristics of patients with primary epithelial ovarian cancer. A cross sectional study. Annals of Medicine and Surgery. 2020 Nov 1;59:254-7.
19. Iglesias Campos M, Pajares B, Roldán Jiménez C, Bermejo-Perez MJ, Alba E, Cuesta Vargas A. Functional status of patients suffering from ovarian cancer: A cross-sectional study.
20. Stenzel AE, Buas MF, Moysich KB. Survival disparities among racial/ethnic groups of women with ovarian cancer: An update on data from the Surveillance, Epidemiology and End Results (SEER) registry. Cancer epidemiology. 2019 Oct 1;62:101580.
21. Palmqvist C, Staf C, Mateoiu C, Johansson M, Albertsson P, Dahm-Kähler P. Increased disease-free and relative survival in advanced ovarian cancer after centralized primary treatment. Gynecologic Oncology. 2020 Nov 1;159(2):409-17.
22. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
23. Institute NC. Cancer stat facts: ovarian cancer. 2019.
24. Machida H, Matsuo K, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kanauchi M, Nagase S, Enomoto T, Mikami M. Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015: A JSGO–JSOG joint study. Gynecologic oncology. 2019 Jun 1;153(3):589-96.
25. Peres LC, Cushing-Haugen KL, Köbel M, et al. Invasive epithelial ovarian cancer survival by histotype and disease stage. J Natl Cancer Inst 2019;111:60-8.
26. Morgan RD, Burghel GJ, Flaum N, Bulman M, Clamp AR, Hasan J, Mitchell CL, Schlecht H, Woodward ER, Lallo FI, Crosbie EJ. Prevalence of germline pathogenic BRCA1/2 variants in sequential epithelial ovarian cancer cases. Journal of medical genetics. 2019 May 1;56(5):301-7.
27. Elshami M, Yaseen A, Alser M, Al-Slaibi I, Jabr H, Ubaiat S, Tuffaha A, Khader S, Khraishi R, Jaber I, Arafeh ZA. Knowledge of ovarian cancer symptoms among women in Palestine: a national cross-sectional study. BMC public health. 2021 Dec;21(1):1-0.
28. Roberts AL, Huang T, Koenen KC, Kim Y, Kubzansky LD, Tworoger SS. Posttraumatic stress disorder is associated with increased risk of ovarian cancer: a prospective and retrospective longitudinal cohort study. Cancer research. 2019 Oct 1;79(19):5113-20.
29. Garrido MP, Salvatierra R, Valenzuela-Valderrama M, Vallejos C, Bruneau N, Hernández A, Vega M, Selman A, Quest AF, Romero C. Metformin reduces NGF-induced tumour promoter effects in epithelial ovarian cancer cells. Pharmaceuticals. 2020 Oct;13(10):315.
30. Sköld C, Bjørge T, Ekbom A, Engeland A, Gissler M, Grotmol T, Madanat-Harjuoja L, Ording AG, Trabert B, Tretli S, Troisi R. Pregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women: a registry-based study. British journal of cancer. 2020 Jul;123(1):161-6.
31. Abreu S, Silva F, Mendes R, Mendes TF, Teixeira M, Santo VE, Boghaert ER, Félix A, Brito C. Patient-derived ovarian cancer explants: preserved viability and histopathological features in long-term agitation-based cultures. Scientific reports. 2020 Nov 10;10(1):1-3.
32. Van der Hel OL, Timmermans M, van Altena AM, Kruitwagen RF, Slangen BF, Sonke GS, van de Vijver KK, Van der Aa MA. Overview of non-epithelial ovarian tumours: Incidence and survival in the Netherlands, 1989–2015. European Journal of Cancer. 2019 Sep 1;118:97-104.
33. Maoz A, Matsuo K, Ciccone MA, Matsuzaki S, Klar M, Roman LD, Sood AK, Gershenson DM. Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord–Stromal Tumors: A Contemporary Review. Cancers. 2020 Jun;12(6):1398.
34. Chen YN, Ma F, Zhang YD, Chen L, Li CY, Gong SP. Ultrasound features improve diagnostic performance of ovarian cancer predictors in distinguishing benign and malignant ovarian tumors. Current medical science. 2020 Feb;40(1):184-91.
35. Inglis JE, Lin PJ, Kerns SL, Kleckner IR, Kleckner AS, Castillo DA, Mustian KM, Peppone LJ. Nutritional interventions for treating cancer-related fatigue: a qualitative review. Nutrition and cancer. 2019 Jan 2;71(1):21-40.
36. Chapman-Davis E, Zhou ZN, Fields JC, Frey MK, Jordan B, Sapra KJ, Chatterjee-Paer S, Carlson AD, Holcomb KM. Racial and ethnic disparities in genetic testing at a hereditary breast and ovarian cancer center. Journal of General Internal Medicine. 2021 Jan;36(1):35-42.
37. Shin DW, Bae J, Ha J, Jung KW. Conditional Relative Survival of Ovarian Cancer: A Korean National Cancer Registry Study. Frontiers in Oncology. 2021;11.