Volume : 09, Issue : 03, March – 2022

Title:

27.EXTRACTION, PHYTOCHEMICAL SCREENING AND EVALUATION OF ANALGESIC & ANTIPYRETIC ACTIVITY OF HYDROALCOHOLIC LEAF EXTRACT OF SOLENUM VIRGINIANUM

Authors :

Kartik Verma, Dr. Deepak Basedia, Dr. B. K. Dubey

Abstract :

Solanum virginianum used by the local people as folk medicines in treating throat infections and other inflammatory problems. The fruits are known for several medicinal uses like anthelmintic, antipyretic, laxative, anti-inflammatory, anti-asthmatic and aphrodisiac activities. The fruit paste is applied externally to the affected area for treating pimples and swellings. The various parts of the plant are reputed in indigenous Hindu Medicine to have high medicinal value in various diseases like cough, asthma, fever, heart disease etc. This study was designed to evaluate different in vitro biological activities like antioxidant activity, antimicrobial activity and in vivo anti-pyretic and analgesic activities of hydroalcoholic extract of leaves of Solanum virginianum The effect of hydroalcoholic extract of leaves of Solanum virginianum were determined after administration at two dose levels (100 and 200 mg/kg b.w.) in yeast induced pyrexia and tail immersion in rats. Our findings suggest a medicinal plant with multiple therapeutic properties that could serve as an antipyretic drug. To elucidate the exact mechanism of action of these active constituents, further investigation is required.
Key words: Solanum virginianum, Hydroalcoholic extract, Analgesic, Antipyretic Activity

Cite This Article:

Please cite this article in press Kartik Verma et al, Extraction, Phytochemical Screening And Evaluation Of Analgesic & Antipyretic Activity Of Hydroalcoholic Leaf Extract Of Solenum Virginianum., Indo Am. J. P. Sci, 2022; 09(3),.

Number of Downloads : 10

References:

1. Balammal G, Sekar BM, Reddy JP. Analysis of Herbal Medicines by Modern Chromatographic Techniques. International Journal of Preclinical and Pharmaceutical Research 2012; 3(1):50-63.
2. Pal KS, Shukla Y. Herbal Medicine: Current Status and the Future. Asian Pacific J Cancer Prev 2003; 4:281-288.
3. Kashaw V, Nema AK, Agarwal A. Hepatoprotective Prospective of Herbal Drugs and Their Vesicular Carriers– A Review. International Journal of Research in Pharmaceutical and Biomedical Sciences 2011; 2(2).
4. Prabhu TP, Panneerselvam P, kumar RV, Atlee WC, Subramanian SB. Anti-inflammatory, anti arthritis and analgesic effect of ethanolic extract of whole plant of Merremia emarginata Burm.F. Central European Journal of Experimental Biology. 2012; 1(3):94-99.
5. Patel P, Patel D, Patel N. Experimental investigation of anti-rheumatoid activity of Pleurotus sajorcaju in adjuvant -induced arthritic rats. Chinese Journal of Natural Medicines. 2012; 10(4):269-274.
6. European Countries, Journal of Pharmacognosy and Phytochemistry. 2012; 1(4).
7. Gautam RK, Singh D, Nainwani R. Medicinal Plants having Anti-arthritic Potential: A Review, Int. J. Pharm. Sci. Rev. Res. 2013; 19(1):96-102.
8. Patil RB, Vora SR, Pillai MM. Protective effect of Spermatogenic activity of Withania somnifera (Ashwagandha) in galactose stressed mice, Annals of Biological Research. 2012; 3(8):4159-4165.
9. Brown HM, Christie AB, Colin EJ. Glycyrrhetinc acid hydrogensuccinate (disodium) salt, a new antiinflammatory compound, Lancet. 1959;2:492.
10. Chattopadhyay D, Arunachalam G, Ghosh L, Rajendran AB, Bhattacharya SK.Antipyretic activity of Alstonia macrophylla Wall exA. DC: An ethnomedicine of Andaman Islands. Journal of Pharmacy and Pharmaceutical Science. 2005; 8:558-564.
11. Spacer CB, Breder CD. The neurologic basic of fever. New England Journal of Medicine. 1994; 330:1880-1886.
12. Veugelers PJ, Kaldor JM, Strathdee SA, Page-Shafer KA, Schechter MT, Coutinho RA, Keet, IP Van Grienseven GJ. Incidence and prognostic significance of symptomatic primary human immuno deficiency virus type Infection in homosexual men. Journal of Infectious Disease. 1997; 176:112-117.
13. Eskerud JRLaerum EFagerthun HLunde PKNaess AA Fever in general practice, I: frequency and diagnosis Fam Pract 1992;9263- 269 PubMed
14. Baucher RGreen-Hernandez CedSingleton JKedAronzon DZed Fever: approach to the febrile child Primary Care Pediatrics. Philadelphia, Pa Lippincott Williams & Wilkins2001;343- 357
15. Guton H Human Physiology and Mechanisms of Disease 6th ed. Philadelphia, Pa WB Saunders1997;
16. Baraff LJBass JWFleisher GR et al. Agency for Health Care Policy and Research, Practice guideline for management of infants and children 0 to 36 months of age with fever without source Ann Emerg Med 1993;221198- 1210 PubMed
17. Rajani G. P., Deepak Gupta, Sowjanya K, and Sahithi B. Screening of antipyretic activity of aerial parts of Nelumbo nucifera gaertn in yeast induced pyrexia . Pharmacologyonline, 2011 1: 1120-1124.
18. Duraisankar M. and Ravichandran V. Antipyretic Potential of Polyherbal Ayurvedic Products. Asian Journal Pharmaceutical and Clinical Research, 2012, 5 (2), 146 – 150.
19. Gupta M., B.P. Shaw and A. Mukerjee. Studies on Antipyretic Analgesic and Ulcerogenic Activity of Polyherbal Preparation in Rats and Mice. Intl.Journal of Pharmacology, 2008, 4(2): 88-94.
20. Ighodaro Igbe, Raymond I Ozolua, Steve O Okpo and Osahon Obasuyi. Antipyretic and analgesic effects of the aqueous extract of the Fruit pulp of Hunteria umbellata K Schum (Apocynaceae) . Tropical Journal of Pharmaceutical Research, 2009, 8(4): 331-336.
21. Khandelwal KR. Ed. Practical Pharmacognosy Technique and Experiments, 23rd Edn: 2005; 15.
22. Kokate CK. Ed. Practical Pharmacognosy, 4th Edn., Vallabh Prakashan: 1994; 112:120.
23. Mukherjee PK. Quality Control of Herbal Drugs, 2nd Edition, Business Horizons, 2007; 2-14.
24. Roopashree TS, Dang R, Rani SRH, Narendra C. Antibacterial activity of anti-psoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis. International Journal of Applied Research in Natural Products 2008; 1(3): 20-28.
25. Obasi NL, Egbuonu ACC, Ukoha PO, Ejikeme PM. Comparative phytochemical and antimicrobial screening of some solvent extracts of Samanea saman pods. African journal of pure and applied chemistry 2010; 4(9): 206-212.
26. Audu SA, Mohammed I, Kaita HA. Phytochemical screening of the leaves of Lophira lanceolata (Ochanaceae). Life Science Journal 2007; 4(4): 7579.
27. Junaid Niazi, Vikas Gupta, Prithviraj Chakarborty and Pawan Kumar. Anti inflammatory and antipyretic activity of Aleuritis moluccana leaves .Asian Journal of Pharmaceutical and Clinical Research, 2010, 3(1): 35-37.
28. Laurence DR, Benneth PN, Brown MJ. Clinical Pharmacology. 8th edn. Edinburgh: ChurchHillLivingstone; 1997.
29. Mate GS, Naikwade NS, Chowki CSA, Patil SB. Evaluation of Anti-nociceptive Activity of Cissus quadrangularis on Albino Mice. Int J Green Pharm. 2008;2:118–121.