Volume : 09, Issue : 03, March – 2022
Title:
29.FORMULATION AND EVALUATION OF POLYHERBAL GEL CONTAINING ROSA ALBA, SANTALUM ALBUM LINN AND OCIMUM SANCTUM FOR TOPICAL FUNGAL INFECTION
Authors :
Antim Shobha Vora, Dr. Sinil Shah, Dr. C. K. Tyagi
Abstract :
Plant based drugs provide outstanding contribution to modern therapeutics as a source of many valuable secondary metabolites which serves as plant defence mechanisms against predator such as microorganism, insects and herbivores which have been proved to be potentially active compounds. There is a tremendous increase in search of antimicrobial plant extracts due to the fact that the resistance offered against antibiotic by the microorganism, in short the effective life span of any antibiotic is limited. Candida albicans is common fungus responsible for the development of various forms fungal disease. In the present study anti-fungal gels were prepared using polymer carbopol 940 along with the hydroalcoholic extracts of flower of Rosa alba L, leaves of Santalum album Linn and Ocimum sanctum Linn and evaluated for their physicochemical properties, like pH, washability, extrudability, spreadability and viscosity. The formulations (PHG1-PHG6) were tested for the anti acne activity by well diffusion method against Candida albicans. Results showed that the gels were non-irritant, stable and posses anti-fungal activity. This study suggests that selected plants have potential against fungus and hence they can be used in topical anti-fungal preparations and may address the antibiotic resistance.
Keywords: Rosa alba, Santalum album, Ocimum sanctum , Candida albicans, Carbopol, Physicochemical properties.
Cite This Article:
Please cite this article in press Antim Shobha Vora et al, Formulation And Evaluation Of Polyherbal Gel Containing Rosa Alba, Santalum Album Linn And Ocimum Sanctum For Topical Fungal Infection., Indo Am. J. P. Sci, 2022; 09(3),.
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References:
1. Molero, G., Orejas, R.D., Garcia, F.N., Monteoliva, L., Pla, J., Gil, C., Parez, M.S., Nombela, C., 1998. Internation. Microbiol.1, 95-106.
2. Chen, S.C.A. and Sorrell, T.C., 2007. Antifungal agents. MJA.187, 404-409.
3. Lucca, A.J.D. and Walsh, T.J., 1999. Antifungal peptides: novel therapeutic compounds against emerging pathogens. Antimicrobial agents and Chemoth.43, 1-11.
4. Pyun, M.S. and Shin, S., 2005. Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole. Phytomed.13, 394-400.
5. Ozcelik, B., Aslan, M., Orhan, I. and Karaglu, T., 2005. Antibacterial, antifungal and antiviral activities of lipophylic extracts of Pistacia vera. Microbiol. Res.160, 159-164.
6. El-Ishaq A. Extraction of limonene from orange peel. Nutr Heavy Met 2015; 1–15.
7. Gotmare S. Orange Peel: A Potential Source of Phytochemical Compounds. Int J ChemTech Res 2018; 7(3): 231.
8. Arunkumar S, Muthuselvam M. Analysis of phytochemical constituents and antimicrobial activities of Aloe vera L. against clinical pathogens. World J Agric Sci 2009; 5(5):572–576.
9. Geeta Parkhe, Deepak Bharti. In Vitro Antioxidant Activity, Total Phenolic and Flavonoid Contents of Hydroalcoholic Extract of Leaves of Lagerstroemia Parviflora Roxb. Journal of Drug Delivery & Therapeutics. 2019; 9(4-A):708-711.
10. Tanaji Nandgude, Rahul Thube, Nitin jaiswal, Pradip deshmukh, Vivek chatap, Nitin hire. Formulation and evaluation of pH induced insitu nasal gel of salbutamol sulphate. Int J Pharma Sci & Nanotechnol 2008; 1 (2): 177-83.
11. Benoy Brata Bhowmik, Bhabani Shankar Nayak, Arkendu Chatterjee. Formulation development and characterization of metronidazole microencapsulated bioadhesive vaginal gel. Int J Pharma and Pharma Pract 2009; 1(1): 240.
12. Maria BR Queiroz, Natália B Marcelino, Marcos V Ribeiro, Laila S Espindola, Franciscor Cunha, Monica V da Silva. Development of gel with Matricaria recutita L. extract for topic application and evaluation of physical-chemical stability and toxicity. Lat Am J Pharma 2009; 28 (4): 574-9.
13. Panigrahi L, Ghosal SK, Pattnaik S, Maharana L, Barik BB. Effect of permeation enhancers on the release and permeation kinetics of lincomycin hydrochloride gel formulations through mouse skin. Indian J Pharm Sci (2006); 68: 205-11.
14. Srisombat Nawanopparatsakul, Jeeratikorn Euasathien, Chuwit Eamtawecharum, Porntip Benjasirimingokol, Sakdanai Soiputtan, Photchanart Toprasri, et al. Skin irritation test of curcuminoids facial mask containing chitosan as a binder. Silpakorn Uni versity J 2005; 5(1-2): 140-7.
15. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4):493-496.