Volume : 09, Issue : 05, May – 2022

Title:

12.A COMPREHENSIVE INSIGHT ON OCULAR DRUG DELIVERY SYSTEM

Authors :

Pratiksha Rampure*, Dr. Archana Barhate

Abstract :

The eye is the most distinctive organ in the human body. Various drug delivery methods are utilised to deliver drugs into the eyes, however because of the drawbacks of conventional systems, researchers are looking for novel approaches to improve contact time, bioavailability, and residence length, as well as minimise patient pain and dosage frequency. 90% of currently available ophthalmic formulations are in conventional dose forms. The ideal ophthalmic drug delivery system must be able to continue drug release for a lengthy period of time while remaining in close contact to the front of the eye. Due to its unique structure and physiology, including multiple types of barriers such as distinct layers of cornea, sclera, and retina, blood aqueous and blood–retinal barriers, choroidal and conjunctival blood flow, and so on, ocular drug delivery has been a big issue for scientists. These obstacles make delivering a single medicine or a dose form to the posterior portion of the eye difficult. To resolve these concerns, novel dosage forms like nanoparticles, liposomes, and microemulsions etc. have been designed. In this review, information on various ocular drug delivery systems, such as eye ointments, gels, and the use of viscosity enhancers, prodrugs, penetration enhancers, microparticles, liposomes, niosomes, ocular inserts, implants, intravitreal injections, nanoparticles, nanosuspension, microemulsion, dendrimers, iontophoresis, and periocular injections is illustrated. Barriers to drug penetration, routes of ocular drug administration, and ways to increase ocular bioavailability were the focus of this review.
Keywords: Ocular absorption, Ocular bioavailability, Nanoparticles, Microemulsion

Cite This Article:

Please cite this article in press Pratiksha Rampure et al, A Comprehensive Insight On Ocular Drug Delivery System., Indo Am. J. P. Sci, 2022; 09(5).,

Number of Downloads : 10

References:

1. Patel PB, Shastri DH, Shelat PK and Shukla AK: Ophthalmic drug delivery system: Challenges and Approaches. Systematic reviews in pharmacy 2010; 1(2): 113-115.
2. Patel A, Cholkar K, Agrahari V and Mitra AK: Ocular drug delivery system: an overview. World journal of pharmacology 2013; 2(2): 47-64.
3. Kumar A, Malviya R and Sharma P: Recent trends in Ocular drug delivery: a short review. European Journal of applied Sciences 2011; 3(3): 86-92.
4. Ramaiyan and Vijaya JR: Ocular drug delivery system- A review. International Journal of Innovative drug discovery 2012; 2(1): 4-15.
5. Paswan SK, Verma P, Yadav MS, Bhowmik D, Gupta S, Azmi L, Shukla I, Bhargava K and Rao CV: Review- advance technique in ocular drug delivery system. World journal of pharmacy and pharmaceutical sciences 2015; 4(5): 346-365.
6. Kumari B: Ocular drug delivery system: Approaches to improve ocular bioavailability. GSC Biological and pharmaceutical Sciences 2019; 06(03): 001-010.
7. Gaudana R, Jwala J, Boddu Sai HS and Mitra K: Recent perspectives in ocular drug delivery. Pharmaceutical research 2009; 26(5).
8. Singh A, Negi D, Mishra N, and Baldi A: Recent trends in ocular drug delivery. Pharmaspire 2018; 10(2): 55-63.
9. Jtirvinena K, Tomi J and Urttia SA: Ocular absorption following topical delivery. Advanced Drug Delivery Rev1995; 16, 3-19.
10. Urtti A: Challenges and obstacles of ocular drug delivery. Advanced drug delivery Rev 2006, 58: 1131-1135.
11. Hajare A, Mali S, Salunkhe S, Nadaf S, Bhatia N, Bagal P, Gaikwad S, and Pawar K: A rational approach to ocular drug delivery system: a overview. World journal of Pharmaceutical research 2014; 3(2): 3324-3348.
12. Tangri P and Khurana S: Basics of ocular drug delivery system. International Journal research in Pharmaceutical, biomedical sciences 2011; 2(4), 1541-1548.
13. Gulati N and Dwivedi V: Review on ocular drug delivery system and its devices. International journal of drug regulatory affairs 2014; 2930, 79-82.
14. Barar J, Javadzadeh AR and Omidi Y: Ocular novel drug delivery: implants of membranes and barriers. Expert opinion drug delivery2008; 5(5), 567-581.
15. Vishal KR, Mazumder R and Madhra M: Ocular drug delivery system: Challenges and approaches. International journal of applied pharmaceutics 2020; 12(5), 49-57.
16. Palani S, Joseph NM, Goda CC, Zachariah A and Ayenew Z: Ocular drug delivery: a review. International journal of pharmaceutical Sciences and research 2010; 1(3).
17. Achouri D, Alhanout K, Piccerelle P and Andrieu V: Recent advances in ocular drug delivery. Drug development and industrial Pharmacy 2012.
18. Ameed U, Javed A, Mohd Q, Khan N and Asgar A: Colloidal drug delivery systems: amplify the ocular delivery. Drug delivery 2016; 23(3): 700-716.
19. Rathore KS, Nema RK and Sisodia SS: An overview and advancement in ocular drug delivery system. International journal of pharmaceutical science and research 2010; 1(10): 11-23.
20. Hyenong MK and Se JW: Ocular drug delivery to the retina: current Innovations, future perspectives. Pharmaceuticals 2021; 13: 108.
21. Shivhare R, Pathak A, Shrivastva N, Singh C, Tiwari G and Goyal R: An update review on Novel Advanced ocular drug delivery system. World journal of Pharmacy and Pharamceutical sciences 2012; 1(2), 545-568.
22. Dubald M, Bourgeois S, Andrieu V and Fessi H: Ophthalmic drug delivery systems for antibiotherapy: a review. Pharmaceutics 2018; 10(1),10.
23. Yerikala R, Kothapalli CB, Reddy J. RP.: A novel approaches of ocular drug delivery system. Journal of drug delivery and therapeutics 2017; 7(6): 117-124.
24. Roy BG and Majee SB: Niosomes in ocular drug delivery. European Journal of Pharmaceutical and Medical research 2017; 4(7), 813-819.
25. Weiner AL and Gilgert BC: Advancement of ocular drug delivery. Veterinary ophthalmology 2010; 13(6): 395-406.
26. Binstock EE and Domb AJ: Iontophoresis: a non-invasive ocular drug delivery. Journal of controlled release 2006; 110(3): 479-489.
27. Yavuz B, Pehlivan SB and Unlu N: Dendrimeric systems and their application in ocular drug delivery. The scientific world journal 2013.
28. Hegde RR, Verma A and Ghosh A: Microemulsion new insights into ocular drug delivery. Hindawi Publishing Corporation ISRN Pharmaceutics 2013.
29. Kalita R and Das B: Novel strategy for improving bioavailability of ocular drug delivery using colloidal nanosuspension. International Journal of Pharmaceutical Sciences and Research 2020; 11(12): 6028-6037.
30. Kang MJ, Rudeen KM, Liu W and Mieler WF: Advances in ocular drug delivery system. Eye 2020; 34: 1371-1379.
31. Dhyani A and Kumar G: A new vision to eye: Novel ocular drug delivery system. Pharmacophore 2019; 10(1): 13-20.
32. Gorantla S, Rapali VK, Waghule T, Singh PP, Dubey SK, Saha RN and Singhvi G: Nanocarriers for ocular drug delivery: current status and translational opportunity. Royal society of chemistry 2020; 10, 27835-27855.
33. Devhadrao NV and Siddaia M: Review on ocular insert drug delivery system. Journal of drug delivery and therapeutics 2018; 3(5-s): 115-121.
34. Gorle AP and Gattani SG: Development and evaluation of ocular drug delivery system. Pharmaceutical development and technology 2010; 15(1): 46-52.
35. Mehrandish S and Mirzaeei S: A review on ocular novel drug delivery systems of antifungal drugs: Functional evaluation and comparison of conventional and novel dosage forms. Adv Pharm Bull 2021, 11(1), 28-38.
36. Bhaskaran S, PK Lakshmi, CG Harish: Topical ocular drug delivery. Indian Journal of Pharmaceutical Science 2005, 67(4): 404-408.
37. Urtti A: Challenges and obstacles of ocular pharmaceutics and drug delivery. Advanced drug delivery reviews 2006; 58: 1131-1135.
38. Sasaki H, Yamamura K, Nishida K, Nakamurat J and Ichikawa M: Delivery of drugs to the eye by topical application. Progress in Retinal and Eye Research 1996, 15(2), 553-620.
39. Jitendra, Sharma PK, Banik A and Dixit S: A New Trend: Ocular Drug Delivery System. International J. of Pharma. Sci. 2011; 2 (3): 1-22.
40. Venkata RG, Madhavi S and Rajesh P: Ocular Drug Delivery: An Update Review. IJPBS 2011; 1(3): 437-446.
41. Alves M, Fonseca EC, Alves MF, Malki LT, Arruda GV and Reinach PS: Dry eye disease treatment: A systematic review of published trials and a critical appraisal of therapeutic strategies. Ocul Surf 2013; 11:181-92.
42. Barathi A and Santhosh KR: Advanced ocular drug delivery systems, Pharma buzz 2007; 2:21-5.
43. Hongming C: Recent developments in ocular drug delivery. Journal of Drug Targeting 2015; 23:7-8, 597-604.