Volume : 09, Issue : 05, May – 2022
Title:
24.AN OVERVIEW: FORMULATION ASPECT OF SOLID DISPERSION AND ITS PHARMACEUTICAL APPLICATION
Authors :
Rayjade R.A.*, Deshmukh T.V., Thavare S.P.
Abstract :
Most common problem with conventional dosage form is solubility, so the new approach in the formulation is solid dispersion. Solubility affects the dissolution and hence the bioavailability of a drug. This review emphasizes methods for improving solubility, carrier selection, classification, advantages, disadvantages, application, characterization, and scope of solid dispersion in formulations other than a tablet. Also involves recent research in solid dispersion formulation with drugs, methods of preparation as well as polymer. Methods of preparation for solid dispersion are highlighted in this article, methods like kneading, solvent evaporation, and fusion can be performed on a lab scale. Solid dispersion enhances the solvation property of the drug by decreasing its particle size and improving wettability. This article introduces the basic concept of solid dispersion along with different types of carriers which can be useful for the formulation of a more stable solid dispersion product. Hence this study involves detailed insight into aspects of solid dispersion and its pertinence in different formulations.
Keywords: Solubility, Solid Dispersion, Dissolution, Bioavailability, Carriers, Wettability.
Cite This Article:
Please cite this article in press Rayjade R.A et al, An Overview: Formulation Aspect Of Solid Dispersion And Its Pharmaceutical Application., Indo Am. J. P. Sci, 2022; 09(5).,
Number of Downloads : 10
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