Volume : 09, Issue : 05, May – 2022
Title:
34.EXTRACTION, ANTIOXIDANT AND IN-VITRO AND IN-VIVO ANTI-ACNE POTENTIAL OF SYMPLOCOS RACEMOSA EXTRACT
Authors :
Ankita Shrivastava*, Mr. Salaj Khare, Dr. Deepak Kumar Basediya, Sandra Gautam,
Dr. B. K. Dubey
Abstract :
Medicinal plants play an important role in the development of potent therapeutic agents. Plant based drugs provide outstanding contribution to modern therapeutics as a source of many valuable secondary metabolites which serves as plant defence mechanisms against predator such as microorganism, insects and herbivores which have been proved to be potentially active compounds. There is a tremendous increase in search of antimicrobial plant extracts due to the fact that the resistance offered against antibiotic by the microorganism, in short the effective life span of any antibiotic is limited. Acne is a common but serious skin disease, which affects approximately 80%adolescents and young adults in 11-30 age groups. 42.5% of men and 50.9% of women continue to suffer from this disease into their twenties. Acne vulgaris (acne) is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory (comedones, open and closed) lesions. Propi¬onibacterium acnes are common pus-forming microbes responsible for the development of various forms of acne. In the present study anti-acne activity of the hydroalcoholic extracts of Leaves of Symplocos racemosa evaluated. In- vitro anti acne of Clindamycin and hydroalcoholic extract of Symplocos racemosa against Propionibacterium acne was performed using well diffusion method. The presence of various phytoconstituents including the leaves extract in Symplocos racemosa i.e. flavanoids, alkaloids showed significant anti-acne properties. In conclusion, the presented data indicate that the administration of hydroalcoholic extract of Symplocos racemosa have potent anti-acne activity.
Keywords: Propionibacterium acnes, Hibiscus Rosa-Sinesis Linn, Embelia Ribes, Allium Cepa Carbopol 940, Anti-acne activity, Well diffusion method, Clindamycin
Cite This Article:
Please cite this article in press Ankita Shrivastava et al, Extraction, Antioxidant And In-Vitro And In-Vivo Anti-Acne Potential Of Symplocos Racemosa Extract., Indo Am. J. P. Sci, 2022; 09(5).,
Number of Downloads : 10
References:
1. Kaur D, Prasad SB. Anti acne activity of acetone extract of Plumbago indica root. Asian J Pharm Clin Res 2016; 9(2):285-7.
2. Gupta MA, Gupta AK. Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. Br J Dermatol 1998; 139(5):846-50.
3. Cunliffe WJ. Natural history of acne. In: Cunliffe WJ, editor. Acne. London: Martin Dunitz; 1989. p. 2-10.
4. Mukherjee PK. Quality Control of Herbal Drugs, 2nd Edition, Business Horizons, 2007; 2-14.
5. Kokate CK. Ed. Practical Pharmacognosy, 4th Edn., Vallabh Prakashan: 1994; 112:120.
6. Roopashree TS, Dang R, Rani SRH, Narendra C. Antibacterial activity of anti-psoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis. International Journal of Applied Research in Natural Products 2008; 1(3): 20-28.
7. Obasi NL, Egbuonu ACC, Ukoha PO, Ejikeme PM. Comparative phytochemical and antimicrobial screening of some solvent extracts of Samanea saman pods. African journal of pure and applied chemistry 2010; 4(9): 206-212.
8. Audu SA, Mohammed I, Kaita HA. Phytochemical screening of the leaves of Lophira lanceolata (Ochanaceae). Life Science Journal 2007; 4(4): 75-79.
9. Geeta Parkhe, Deepak Bharti. Phytochemical Investigation and Determination of Total Phenols and Flavonoid Concentration in Leaves Extract of Vitex trifolia Linn. Journal of Drug Delivery & Therapeutics. 2019; 9(4-A):705-707.
10. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4):493-496.
11. Miliauskas G, Venskutonis PR and Van Beek TA. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chemistry. 2004; 85(2):231-7.
12. OECD, Guideline for Testing of Chemicals-Acute Oral Toxicity-AcuteToxic Class Method. Paris: OECD; 2001.
13. Pandey C, Karadi RV, Bhardwaj LK, Sahu AK. Screening of selected herbal plants for anti acne properties. Int. J. Drug Dev. & Res. 2012; 4(2):216-22.