Volume : 09, Issue : 05, May – 2022

Title:

37.DEVELOPMENT AND CHARACTERIZATION OF NOVEL CARRIER FOR DRUG DELIVERY OF ANTIFUNGAL DRUG

Authors :

Neetesh Jain*, Dr. Akhilesh Kumar Singhai, Ms. Steffi Thomas

Abstract :

Fungal infections are the most common diseases found in tropical countries like India, but these infections are neglected and hence spread to other parts of the body. The most commonly used antifungal agents are Miconazole, these molecules being imidazole derivatives with high lipophilicity. It act against most pathogenic fungi and some Gram- positive bacteria. Usually, they are well tolerated and their low toxicity allows them to be safely used for treating several cutaneous or systemic infections. Encouraging results have been obtained on the treatment of topical fungal infections with liposomal or novel vesicular formulations of these antifungal drugs, but due to their size and rigid lipid bilayer they were not able to penetrate efficiently across the skin layer. The transfersome preparations containing Miconazole are conceptually sophisticated; they are characterized by simplicity in their preparation, good stability, safety and efficacy that can highly expand their application in the treatment of fungal infections.
Keywords: Fungal infection, Miconazole, Transfersome ,Drug delivery system, Antifungal drugs.

Cite This Article:

Please cite this article in press Neetesh Jain et al, Development And Characterization Of Novel Carrier For Drug Delivery Of Antifungal Drug., Indo Am. J. P. Sci, 2022; 09(5).,

Number of Downloads : 10

References:

1. Panigrahi L, Ghosal SK, Pattnaik S, Maharana L, Barik BB. Effect of permeation enhancers on the release and permeation kinetics of lincomycin hydrochloride gel formulations through mouse skin. Ind J Pharm Sci. 2006; 68: 205-11.
2. Csóka I, Csányi E, Zapantis G, Nagy E, Fehér-Kiss A, Horváth G, Blazsó G, Eros I.In vitro and in vivo percutaneous absorption of topical dosage forms: Case studies. Int J Pharm.2005; 291:11-19.
3. Ng SF, Rouse JJ, Sanderson FD, Meidan V, Eccleston GM. Validation of a static Franz diffusion cell system for in vitro permeation studies.AAPS Pharm Sci Tech. 2010; 11: 1432-41.
4. Simon GA, MaibachHI. The pig as an experimental animal model of percutaneous permeation in man qualitative and quantitative observations – an overview.Skin Pharmacol Appl Skin Physiol.2000; 13: 229–34.
5. Dick IP, Scott RC. Pig ear skin as an in vitro model for human skin permeability. J Pharm Pharmacol.1992; 44: 640–45.
6. Barry AL, Pfaller MA, Rennie RP etal. Precision and accuracy of fluconazole susceptibility testing by broth microdilution, Etest, and disk diffusion methods. Antimicrob Agents Chemother. 2002; 46: 1781-84.
7. Yenisehirli G,Tuncoglu E,Yenisehirli A,Bulut Y.In vitro activities of antifungal drugs against dermatophytes isolated in Tokat, Turkey. Int J Dermatol 2013; 52:1557-60.
8. Goswami S, Nakhuru KS, Das J , Srivastava RB. Phytochemicals and antidermatophytic activity of methanolic extract of Cestrum nocturnum leaves. Ind Drugs. 2009 ; 46: 619-22.
9. Pakshir K, Bahaedinie L, Rezaei Z, Sodaifi M, Zomorodian K. Invitro activity of six antifungal drugs against clinically important dermatophytes. Jundishapur J Microbiol. 2009; 2: 158-63.
10. Barros ME, Santoro DA, Hamdan JS. In vitro methods for antifungal susceptibility testing of Trichophyton sp. Mycol Res. 2006; 110: 1355- 60.
11. Crowley P.J., Martini L.G.Drug-excipient Interactions, Pharm Technol.2001; 13, 1-6.
12. Barboza F., Vecchia D.D., Tagliari M. P., Silva M. A. S., Stulzer H. K. Differential scanning calorimetry as a screening technique in compatibility studies of acyclovir extended release formulations, Pharmaceutical Chem Journal .2009; 43:363-368.