Volume : 09, Issue : 05, May – 2022
Title:
50.EXAMINE THE VIT-D STATUS OF HCV INFECTED PATIENTS AND CONTROL IN RAWALPINDI, PAKISTAN
Authors :
Aleena Shahid, Dr Iffat Saeed, Dr Zainab Asad
Abstract :
Objective: Serum Vitamin-D has an important part in inflammatory and infections illnesses, particularly liver diseases. The purpose of this experiment was to examine the Vitamin-D status of HCV-diseased cases and control in Lahore, Pakistan.
Methods: From August TO September 2021 in BBH, Rawalpindi, we conducted randomized cross-sectional research on 78 people at BBH, Rawalpindi. Fifty-one individuals tested positive for hepatitis C RNA-PCR (25 salaried cirrhotic and 25 decompensated cirrhotic cases). In addition, 24 healthy controls were selected who did not have liver problems. ARTUS ® HCV QS-RGQ V1 was used to perform HCV RNA–PCR. Chemiluminescence was used to determine vitamin D levels. For descriptive statistics, SPSS version 20 was employed.
Results: When compared to untreated (32.43 ng/mL), average level of Vitamin-D in Treated patients remained considerably inferior in supplied and fluid resuscitation hepatocellular carcinoma (28.88 ng/mL & 21.67 ng/mL, respectively). In this research, 78.6 percent of HCV patients had suboptimal Vitamin-D levels. Vitamin-D deficiency (22-28 ng/mL) was seen in both healthy people (46.9 percent) and HCV sufferers (38.3 percent) (P 0.002). Furthermore, Vitamin-D levels were shown to have an inverse association with more multi – organ failure, having 56.3 percent of respiratory failure cirrhosis people undergoing from Vitamin-D insufficiency, relative to 14.7 percent in the recovered cirrhotic groups (P 0.0002).
Conclusion: Suboptimal levels of Vitamin-D (inadequacy before lack) remain more common in hepatitis C comparison to well controls. Vitamin-D insufficiency were found to be directly related to somatic symptoms.
Keywords: Serum Vitamin-D, inflammatory and infections illnesses, HCV-infected.
Cite This Article:
Please cite this article in press M. S. Kalshetti et al, Development And Validation Of UV Spectrophotometric Method For Estimation Of Lenalidomide In Capsule., Indo Am. J. P. Sci, 2022; 09(5).,
Number of Downloads : 10
References:
1. World Health Organization. Rolling updates on coronavirus disease (COVID-19). 2020 Jul 31 [cited 2020 Jul 31]. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen. [Google Scholar]
2. World Health Organization. Timeline of WHO’s response to COVID-19. 2020 Jul 30 [cited 2020 Jul 31]. https://www.who.int/news-room/detail/29-06-2020-covidtimeline. [Google Scholar]
3. COVID-19 Dashboard by the center for systems science and engineering (CSSE) at Johns Hopkins university. 2020 Jul 31 [cited 2020 Jul 31]. https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6. [Google Scholar]
4. World Health Organization. WHO coronavirus disease (COVID-19) dashboard. 2020 Jul 31 [cited 2020 Jul 31]. https://covid19.who.int/. [Google Scholar]
5. Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. The possible role of vitamin D in suppressing cytokine storm and associated mortality in COVID-19 patients. MedRxiv. 2020.04.08.20058578. doi:https://doi.org/10.1101/2020.04.08.20058578. [Crossref], [Google Scholar]
6. Undela K, Gudi SK. Assumptions for disparities in case-fatality rates of coronavirus disease (COVID-19) across the globe. Eur Rev Med Pharmacol Sci. 2020;24(9):5180–2. doi:https://doi.org/10.26355/eurrev_202005_21215. [PubMed], [Web of Science ®], [Google Scholar]
7. Zhao X, Zhang B, Li P, Ma C, Gu J, Hou P, Guo Z, Wu H, Bai Y. Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis. MedRxiv. 2020.03.17.20037572. doi:https://doi.org/10.1101/2020.03.17.20037572. [Crossref], [Google Scholar]
8. Bikle D. Vitamin D: Production, metabolism, and mechanisms of action. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext (Internet). South Dartmouth (MA): MDText.com, Inc.; 2000. (76 pages). https://www.ncbi.nlm.nih.gov/books/NBK278935/. [Google Scholar]
9. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 2016;96(1):365–408. doi:https://doi.org/10.1152/physrev.00014.2015. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]
10. Colotta F, Jansson B, Bonelli F. Modulation of inflammatory and immune responses by vitamin D. J Autoimmun. 2019;85:78–97. doi:https://doi.org/10.1016/j.jaut.2017.07.007. [Crossref], [PubMed], [Web of Science ®], [Google Scholar]