Volume : 09, Issue : 05, May – 2022
Title:
60.EXTRACTION, PHYTOCHEMICAL SCREENING AND EVALUATION OF PLANT OCIMUM SANCTUM AND OCIMUM BASILICUM ACTING AGAINST CNS DEPRESSANT
Authors :
Som Prakash Sahu, Dr. Manju Prajapati, Dr. Pradeep Kumar Mohanty, Dr. Janki Prasad Rai, Dr. A. K. Singhai
Abstract :
Ocimum sanctum and Ocimum basilicum L which has many therapeutic uses, the plant is used as an antibacterial, dysentery, diarrhoea, persistent fever, cough, stomachache, wounds, cuts, burns, fractures, general weakness, antispasmodic, diureticetc, rheumatic, etc. from the earliest times. The plants contain quercetin, essential oil, tannin and various phytosterols, etc. So far, there has been no substantial work on the medicinal use of these plants. Consequently, the current study has been planned to discover the CNS activity of Ocimum sanctum and Ocimum basilicum L. The total phenolic content 0.214 mg/100mg of dry weight of extract, expressed as gallic acid equivalents. The total flavonoid concentrations 0.452 mg/100mg, expressed as quercetin equivalents. Phytochemical Test of prepared extract was performed by standard method. Data for total phenolic and total flavonoid content, data shows that moderate amount of total phenols and total flavonoids are present in the extract and the amounts are 0.352mg Gallic acid /100mg dry wt and 0.620 mg Quercetin/100mg dry wt of dried extract of Ocimum basilicum respectively. The effect Ocimum basilicum shows better results as compaired to that of Ocimum sanctum. The climbing time significantly increased only in Ocimum basilicum as compared to vehicle control. In the TST model in mice there was a significant decrease in immobility time in all the groups as compared to vehicle control. The anti immobility effect of Ocimum basilicum was significant as comparable to that of Ocimum sanctum. Ocimum sanctum and Ocimum basilicum may be developed as an antidepressant drugs. Further research is required to gain closer insights into the exact mechanism of its action.
Key words: Ocimum sanctum and Ocimum basilicum, CNS Activity,
Cite This Article:
Please cite this article in press Som Prakash Sahu et al, Extraction, Phytochemical Screening And Evaluation Of Plant Ocimum Sanctum And Ocimum Basilicum Acting Against CNS Depressant., Indo Am. J. P. Sci, 2022; 09(5).
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