Volume : 09, Issue : 05, May – 2022

Title:

65.ENDOCRINE CHANGES THAT OCCUR DURING SURGERY

Authors :

Faisal H. Alsarrani, Ahmad S. Almutairi , Ebtehal H. Alsarrani

Abstract :

Surgical interventions elicit an endocrine reaction that leads to the mobilization of substrates, thereby inducing a shift in metabolism toward catabolism. The observed metabolic modification is distinguished by the presence of a deleterious nitrogen imbalance and the consequential accumulation of sodium and water within the body. The magnitude of this physiological response exhibits a positive linear relationship with the severity of the surgical trauma. The magnitude of this physiological response exhibits a positive linear relationship with the severity of the surgical trauma. Intra-abdominal procedures have been observed to elicit a significantly heightened physiological response compared to body surface surgery. Similarly, cardiac surgery involving cardiopulmonary bypass has been found to induce substantial alterations in hormonal and biochemical profiles. The existing body of literature pertaining to the endocrine and metabolic effects of surgical procedures is extensive and frequently characterized by contradictory findings and conclusions. The primary objective of this concise article isn’t to offer an exhaustive examination of the topic, but rather to furnish the essential contextual knowledge that will facilitate the comprehension and analysis of the findings presented in more comprehensive investigations.

Cite This Article:

Please cite this article in Faisal H. Alsarrani et al Endocrine Changes That Occur During Surgery, Indo Am. J. P. Sci, 2022; 09 (05).

Number of Downloads : 10

References:

1. Äärimaa, M., Slätis, P., Haapaniemi, L., & Jeglinsky, B. (1974). Glucose tolerance and insulin response during and after elective skeletal surgery. Annals of Surgery, 179(6), 926.
2. Allison, S. P. (1971). Changes in insulin secretion during open heart surgery. British journal of anaesthesia, 43(2), 138-143.
3. Allison, S. P., Tomlin, P. J., & Chamberlain, M. J. (1969). Some effects of anaesthesia and surgery on carbohydrate and fat metabolism. British journal of anaesthesia, 41(7), 588-593.
4. Brandt, M. R., Skovsted, L., Kehlet, H., & Hansen, J. M. (1976). Rapid decrease in plasma-triiodothyronine during surgery and epidural analgesia independent of afferent neurogenic stimuli and of cortisol. The Lancet, 308(7999), 1333-1336.
5. Clarke, R. S. J., JOHNSTON, H., & Sheridan, B. (1970). The influence of anaesthesia and surgery on plasma cortisol, insulin and free fatty acids. BJA: British Journal of Anaesthesia, 42(4), 295-299.
6. Clutter, W. E., Bier, D. M., Shah, S. D., & Cryer, P. E. (1980). Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. The Journal of Clinical Investigation, 66(1), 94-101.
7. Cooper, G. M., Paterson, J. L., Mashiter, K., & Hall, G. M. (1980). Beta-adrenergic blockade and the metabolic response to surgery. BJA: British Journal of Anaesthesia, 52(12), 1231-1236.
8. GEORGE, J. M., REIER, C. E., LANESE, R. R., & ROWER, J. M. (1974). Morphine anesthesia blocks cortisol and growth hormone response to surgical stress in humans. The Journal of Clinical Endocrinology & Metabolism, 38(5), 736-741.
9. Hinton, P., Littlejohn, S., Allison, S. P., & Lloyd, J. (1971). Insulin and glucose to reduce catabolic response to injury in burned patients. The Lancet, 297(7703), 767-769.
10. Johnston, I. D. (1964). Endocrine Aspects of the Metabolic Response to Surgical Operation: Hunterian Lecture delivered at the Royal College of Surgeons of England on 7th April 1964. Annals of the Royal College of Surgeons of England, 35(5), 270.
11. OYAMA, T., Aoki, N., & Kudo, T. (1972). Effect of Halothane Anesthesia and of Surgery on Plasma Testosterone Levels in Men. Anesthesia & Analgesia, 51(1), 130-133.
12. PR, B. (1971). Influence of prolonged epidural blockade on blood sugar and cortisol response to operations upon the upper part of the abdomen and the thorax. Surg Gynecol Obstet, 132, 1051-1056.
13. Stanley, T. H., Berman, L., Green, O., Robertson, D. H., & Roizen, M. (1979, September). Fentanyl-oxygen anesthesia for coronary artery surgery: Plasma catecholamine and cortisol responses. In The Journal of the American Society of Anesthesiologists (Vol. 51, No. 3, pp. S140-S140). The American Society of Anesthesiologists.
14. Traynor, C., & Hall, G. M. (1981). Endocrine and metabolic changes during surgery: anaesthetic implications. BJA: British Journal of Anaesthesia, 53(2), 153-160.
15. Unger, R. H. (1971). Glucagon physiology and pathophysiology. New England Journal of Medicine, 285(8), 443-449.
16. Wilmore, D. W., Long, J. M., Mason, A. D., & Pruitt, B. A. (1976). Stress in surgical patients as a neurophysiologic reflex response. Surgery Gynecology and Obstetrics, 142(2), 257-269.