Volume : 09, Issue : 11, November – 2022

Title:

10.A REVIEW ON EUPATORIUM ADENOPHORUM ANTI-INFLAMMATORY GEL

Authors :

C.Mohana, Arun.Vaishnavi, G. Yuktha Rani, M. Kishore Babu

Abstract :

Herbal formulation means a dosage form consisting of one or more herbs or processed herbs in specified quantities to provide specific nutritional, cosmetics benefits meant for use to diagnose, treat, mitigate disease of human beings or animals.The main aim of the present study is to evaluate and formulation of herbal gel containing extract from the leaves of eupatorium adenophorum for its topical anti-inflammatory activity against carrageenan induced odema .1%w/w concentration of Carbopol -934 is used as gelling agent in this study. The leaves are dried under shade and then powdered coarsely with mechanical grinder. The powder leaves extracted with methanol as solvent by using hot extraction using Soxhlet apparatus. The residue is formed after filtered while preparing gel formulation in the extract residue gelling agent and triethanolamine few quantities is added to adjust ph. To evaluate the formulation through following parameters ph., stability, spreadability, extrudability, and stability also examined. The ph. For all formulation was near about 6.8, which lies in the normal ph. range of the skin. The preparation was stable under normal storage condition and did not produce any skin irritation., erythema and oedema for about month, when over the skin.
Keywords: Eupatorium adenophorum, Carbopol -934, Carrageenan, Stability, Oedema.

Cite This Article:

Please cite this article in press C.Mohana et al, A Review On Eupatorium Adenophorum Anti-Inflammatory Gel.,Indo Am. J. P. Sci, 2022; 09(11).

Number of Downloads : 10

References:

1. D. L. Simmons, “What makes a good anti-inflammatory drug target?” Drug Discovery Today, vol. 11, no. 5-6, pp. 210–219, 2006.
2. K. Saukkonen, S. Sande, C. Cioffe et al., “The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis,” Journal of Experimental Medicine, vol. 171, no. 2, pp. 439–448, 1990.
3. N. L. Parenteau and J. Hardin-Young, “The biological mechanisms behind injury and inflammation: how they can affect treatment strategy, product performance, and healing,” Wounds, vol. 19, no. 4, pp. 87–96, 2007.
4. L. M. Fabbri, M. Saetta, G. Picotti, and C. E. Mapp, “Late asthmatic reactions, airway inflammation and chronic asthma in toluene-diisocyanate-sensitized subjects,” Respiration, vol. 58, no. 1, pp. 18–21, 1991.
5. R. J. Stevens, K. M. J. Douglas, A. N. Saratzis, and G. D. Kitas, “Inflammation and atherosclerosis in rheumatoid arthritis,” Expert Reviews in Molecular Medicine, vol. 7, no. 7, pp. 1–24, 2005.
6. L. Klareskog, L. Padyukov, J. Rönnelid, and L. Alfredsson, “Genes, environment and immunity in the development of rheumatoid arthritis,” Current Opinion in Immunology, vol. 18, no. 6, pp. 650–655, 2006.
7. M. Simka, “Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis,” Current Neurovascular Research, vol. 6, no. 2, pp. 132–139, 2009.
8. R. D. Zipser, “Mediators of inflammation in inflammatory bowel disease,” Digestive Diseases and Sciences, vol. 33, no. 3, pp. 4S–5S, 1988.
9. J. Drews and S. Ryser, “Classic drug targets,” Nature Biotechnology, vol. 15, pp. 1318–1319, 1997.
10. D.-X. Kong, X.-J. Li, and H.-Y. Zhang, “Where is the hope for drug discovery? Let history tell the future,” Drug Discovery Today, vol. 14, no. 3-4, pp. 115–119, 2009.
11. B. A. Auld and P. M. Martins, “The autecology of Eupatorium adenophorum Spreng. In Austraha,” Weed Research, vol. 15, pp. 27–31, 1975.
12. L. Muschietti, M. Derita, V. Sülsen et al., “In vitro antifungal assay of traditional Argentine medicinal plants,” Journal of Ethnopharmacology, vol. 102, no. 2, pp. 233–238, 2005.
13. E. Ahmed, M. Arshad, M. Ahmad, M. Saeed, and M. Ishaque, “Ethnopharmacological survey of some medicinally important plkants of Galliyat areas of NWFP, Pakistan,” Asian Journal of Plant Sciences, vol. 3, pp. 410–415, 2004.
14. P. Castillo-España, A. Cisneros-Estrada, M. L. Garduño-Ramírez, O. Hernández-Abreu, R. Ramírez, and S. Estrada-Soto, “Preliminary ethnopharmacological survey of plants used in Mexico for the treatment of hypertension,” Pharmacognosy Reviews, vol. 3, pp. 41–65, 2009.
15. A. Pieroni, M. E. Giusti, C. de Pasquale et al., “Circum-Mediterranean cultural heritage and medicinal plant uses in traditional animal healthcare: a field survey in eight selected areas within the RUBIA project,” Journal of Ethnobiology and Ethnomedicine, vol. 2, pp. 16–27, 2006.
16. M. Heinrich, M. Robles, J. E. West, B. R. Ortiz De Montellano, and E. Rodriguez, “Ethnopharmacology of Mexican Asteraceae (Compositae),” Annual Review of Pharmacology and Toxicology, vol. 38, pp. 539–565, 1998.
17. N. R. Monks, A. Ferraz, S. A. Bradgnon, K. R. Machado, M. F. Richter, and A. B. DaRocha, “Invitro cytotoxicity of extracts from Brazilian Asteraceae,” Pharmaceutical Biology, vol. 40, pp. 494–500, 2002.
18. E. K. Akkol, U. Koca, I. Pesin, and D. Yilmazer, “Evaluation of the wound healing potential of Achillea biebersteinii Afan. (Asteraceae) by in vivo excision and incision models,” Evidence-Based Complementary and Alternative Medicine. In press.
19. J. Uddin, I. D. Grice, and E. Tiralongo, “Cytotoxic effects of Bangladeshi plant extracts,” Evidence-Based Complementary and Alternative Medicine. In press.
20. Wood JH, Catacalos G, Liberman SV. Adaptation of commercial viscometers for special applications in pharmaceutical rheology Severs extrusion rheometer. J Pharm Sci 1963; 52:375‐378
21. Jadhav KR, Shetye SL, Kadam VJ. Design and Evaluation of Microemulsion Based Drug Delivery System. International Journal of Advances in Pharmaceutical Sciences 2010; 1:156-166.
22. ICH guidelines. Stability testing of new drug substances and products , 27 th October 1993.