Volume : 09, Issue : 11, November – 2022
Title:
20.FORMULATION AND EVALUATION OF FLOATING TABLET OF ALFUZOSIN HCL
Authors :
Gangavarapu Nadia Psalms*,Shilpa Allabotharam,Dr.Khaja Zeeyauddin, Shaik Ejas
Abstract :
The present work was to prepare and optimized floating tablet of Alfuzosin HCl. Alfuzosin HCl is an alfa-1 adrenergic receptor blocker for the treatment of benign prostatic hyper pleasia & hypertension which are design to increase the gastric residence time, thus prolonging the drug release. Alfuzosin HCL has the short biological half -life (3-5hrs) the dose may range from 2.5mg thrice a day to maximum of 10mg once a day which results into inconveniency to the patients. By preparing the floating tablets of Alfuzosin HCl that deliver the drug for longer time, reduced dosage frequency & better patient compliance. The tablets were prepared by direct compression method by using different polymers like HPMC K4M, carbapol 934, xanthum gum, guar gum, sodium bicarbonate & citric acid as gas generating agent with magnesium stearate, micro crystalline cellulose & talc as lubricants and glidant respectively. All the batches were evaluated for pre compression & post compression parameters and results were in the limits. All the batches exhibited appropriate floating lag time with in prescribed limits ( Key words: Alfuzosin HCl ,HPMCK4M, xanthum gum, guar gum, carbapol 934 , sodium bicarbonate citric acid, magnesium sterate, micro crystalline cellulose& talc
Cite This Article:
Please cite this article in press Gangavarapu Nadia Psalms et al, Formulation And Evaluation Of Floating Tablet Of Alfuzosin Hcl.., Indo Am. J. P. Sci, 2022; 09(11).
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