Volume : 09, Issue : 11, November – 2022
Title:
34.SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME PYRIMIDINE DERIVATIVES
Authors :
Shashikant Tripathi, Ramujagar Singh, Dhruva Kumar, Jitendra Kumar, Utkarsh Singh
Abstract :
The main objective of present work is to synthesis, characterization, and evaluation of antimicrobial activity of some pyrimidine derivatives containing O, N, and S in the ring. Pyrimidine derivatives were prepared in three steps. In the initial step, chalcones containing -NO2 functional group were synthesized using Claisen Schmidt condensation of aromatic aldehydes with 2-acetyl pyridine/3-acetylpyridine in methanol in the presence of aqueous NaOH. In the next step, -NO2 group was reduced to -NH2 group. Resulting compounds containing NH2 functional group were reacted with different dichlorothienopyrimidines and dichlorofuropyrimidines in the presence of N,N-diisopropylethylamine to obtain pyrimidine derivatives. Antibacterial and antifungal activity of pyrimidine derivatives were studied in vitro. Pyrimidine derivatives were synthesized and purified using column chromatography. Purity of synthesized pyrimidines was determined by HPLC. Pyrimidines were characterized by different analysis such as elemental analysis, infrared, nuclear magnetic resonance, and mass spectral analysis. Analytical data of synthesized pyrimidines indicates the proposed structures. Finally antibacterial and antifungal activity were observed in the synthesized pyrimidine derivatives.
Keywords: Antibacterial, antifungal, chromatography, spectral, medicines
Cite This Article:
Please cite this article in press Shashikant Tripathi et al, Synthesis, Characterization And Antimicrobial Evaluation Of Some Pyrimidine Derivatives.,Indo Am. J. P. Sci, 2022; 09(11).
Number of Downloads : 10
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