Volume : 09, Issue : 10, October – 2022
14.EFFECTS OF DOBUTAMINE AND ISOPRENALINE ON HEART RATE AFTER DRUG ADMINISTRATION AND INDUCED CADIAC STRESS TEST
Ahmed Shuwaylah, Nawaf Albeladi, Osama Alsahafi, Alaa Alghanmi, Bander Almuabadi, Mohammed Almutairi, Ahmad Mousa, Sameer Alsahafi, Faris Alsahafi, Haitham Abdo Yousef, Ahmed Mulehi, Wajdy Alsahafi, Sharaf Almaramhi, Lujain Altayeb
Purpose; The Purpose of this research is to investigate potency of Isoprenaline, Dobutamine and adrenaline as agonist drugs at absence and presence of the antagonist drugs; that is Metoprolol and prazosin.
Methods; The study employed a total of 30 participants aged between 25 and 45 years who were suffering from cardiovascular disease and two distinct stress test were conducted; that is the drug-induced test and the control-induced test.
Results; Dobutamine is found as the most stable agonist drug as compared to both Isoprenaline and adrenaline. When Isoprenaline and adrenaline agonist drugs are prescribed at high levels or dose, their effectiveness decreases while Dobutamine agonist when prescribed at higher levels or dose its effectiveness increases. Further, from the results, Metoprolol is found as better antagonist drug as compared to Prazosin drugs. In addition, a high level or dose of Dobutamine agonist drugs is needed to neutralize the impact of Metoprolol drugs. On the other hand, Prazosin drugs impact is very weak to block activities of the Dobutamine drugs. In exercise-induced stress test, it is clear that Metoprolol drugs are better antagonist drugs than Prazosin drugs. This is because, Metoprolol drugs significantly lowers individual’s heart rate where Prazosin drugs neither shows an increase nor a decrease in the heart rate.
Conclusion; Isoprenaline and adrenaline are better and appropriate agonist drugs when prescribed at a lower dosage. However, Dobutamine drugs are better and appropriate agonist drugs as compared to Isoprenaline and adrenaline drugs when prescribed at higher dose. Metoprolol is a better antagonist drug as compared to Prazosin drugs since it is able to block activities of the Dobutamine drugs at a low to moderate dose.
Cite This Article:
Please cite this article in Ahmed Shuwaylah et al, Effects Of Dobutamine And Isoprenaline On Heart Rate After Drug Administration And Induced Cadiac Stress Test., Indo Am. J. P. Sci, 2022; 09(10).
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1. Al-Hesayen, A., Azevedo, E. R., Newton, G. E., & Parker, J. D. (2002). The effects of dobutamine on cardiac sympathetic activity in patients with congestive heart failure. Journal of the American College of Cardiology, 39(8), 1269-1274.
2. Butterworth, J. F., Prielipp, R. C., Royster, R. L., Spray, B. J., Kon, N. D., Wallenhaupt, S. L., & Zaloga, G. P. (1992). Dobutamine increases heart rate more than epinephrine in patients recovering from aortocoronary bypass surgery. Journal of cardiothoracic and vascular anesthesia, 6(5), 535-541.
3. De Backer, D., Creteur, J., Dubois, M. J., Sakr, Y., Koch, M., Verdant, C., & Vincent, J. L. (2006). The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects*. Critical care medicine, 34(2), 403-408.
4. Leier, C. V., Heban, P. T., Huss, P. A. T. R. I. C. I. A., Bush, C. A., & Lewis, R. P. (2008). Comparative systemic and regional hemodynamic effects of dopamine and dobutamine in patients with cardiomyopathic heart failure. Circulation, 58(3), 466-475.
5. Saad, W., Guarda, I. F., Camargo, L., Santos, T., Saad, W. A., Guarda, R. S., et al. (2003). Role of nitric oxide of the median preoptic nucleus (MnPO) in the alterations of salivary flow, arterial pressure and heart rate induced by injection of pilocarpine into the MnPO and intraperitoneally. Brazilian Journal of Medical and Biological Research , 897-905.
6. Silverthorn, D. U. (2009). Human physiology. San Francisco: Pearson Education.
7. Stabler, S. P. (2009). PhysioEx 8.0 for Human Physiology: Laboratory simulations in physiology. San Francisco: Pearson Education.